Fabrication and in vitro dissolution evaluation of low-crystalline β-TCP blocks through aqueous solution mediated phase conversion

Garima Tripathi, Kunio Ishikawa

Research output: Contribution to journalArticlepeer-review

Abstract

Magnesium substituted low crystalline β‑tricalcium phosphates (LC-β-TCP) is an attractive biomaterials owing to its high initial osteoconductivity and bone regeneration. The present investigation is focused on fabrication of low crystalline β-TCP (LC-β-TCP) and evaluating in vitro dissolution toward to the crystallinity of the LC-β-TCP. It is suggested that the crystallinity of biocompatible ceramics greatly affect into their biocompatibility. The novelty of the work is the preparation of the LC-β-TCP without any calcium carbonate/phosphate complex, which is commonly in use. LC-β-TCP was fabricated from MgHPO 4 ·3H 2 O (MgP) and CaCl 2 aqueous solution at 200 °C hydrothermal condition. In vitro dissolution evaluations simulated osteoclast condition indicated the release of Mg 2+ and Ca 2+ . It is suggested that LC -β-TCP fabricated by the given method could be useful material for bone regeneration because it has both low crystallinity and suitable Ca 2+ and Mg 2+ releasing and most importantly it does not contain any extended protocol.

Original languageEnglish
Pages (from-to)228-231
Number of pages4
JournalMaterials Science and Engineering C
Volume101
DOIs
Publication statusPublished - Aug 1 2019

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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