Fabrication and in vitro dissolution evaluation of low-crystalline β-TCP blocks through aqueous solution mediated phase conversion

Garima Tripathi, Kunio Ishikawa

Research output: Contribution to journalArticle

Abstract

Magnesium substituted low crystalline β‑tricalcium phosphates (LC-β-TCP) is an attractive biomaterials owing to its high initial osteoconductivity and bone regeneration. The present investigation is focused on fabrication of low crystalline β-TCP (LC-β-TCP) and evaluating in vitro dissolution toward to the crystallinity of the LC-β-TCP. It is suggested that the crystallinity of biocompatible ceramics greatly affect into their biocompatibility. The novelty of the work is the preparation of the LC-β-TCP without any calcium carbonate/phosphate complex, which is commonly in use. LC-β-TCP was fabricated from MgHPO 4 ·3H 2 O (MgP) and CaCl 2 aqueous solution at 200 °C hydrothermal condition. In vitro dissolution evaluations simulated osteoclast condition indicated the release of Mg 2+ and Ca 2+ . It is suggested that LC -β-TCP fabricated by the given method could be useful material for bone regeneration because it has both low crystallinity and suitable Ca 2+ and Mg 2+ releasing and most importantly it does not contain any extended protocol.

Original languageEnglish
Pages (from-to)228-231
Number of pages4
JournalMaterials Science and Engineering C
Volume101
DOIs
Publication statusPublished - Aug 1 2019

Fingerprint

phosphates
dissolving
Dissolution
Phosphates
Crystalline materials
aqueous solutions
Fabrication
fabrication
evaluation
crystallinity
regeneration
bones
Bone
Calcium Carbonate
calcium carbonates
Calcium carbonate
Biocompatible Materials
releasing
biocompatibility
Biocompatibility

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

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title = "Fabrication and in vitro dissolution evaluation of low-crystalline β-TCP blocks through aqueous solution mediated phase conversion",
abstract = "Magnesium substituted low crystalline β‑tricalcium phosphates (LC-β-TCP) is an attractive biomaterials owing to its high initial osteoconductivity and bone regeneration. The present investigation is focused on fabrication of low crystalline β-TCP (LC-β-TCP) and evaluating in vitro dissolution toward to the crystallinity of the LC-β-TCP. It is suggested that the crystallinity of biocompatible ceramics greatly affect into their biocompatibility. The novelty of the work is the preparation of the LC-β-TCP without any calcium carbonate/phosphate complex, which is commonly in use. LC-β-TCP was fabricated from MgHPO 4 ·3H 2 O (MgP) and CaCl 2 aqueous solution at 200 °C hydrothermal condition. In vitro dissolution evaluations simulated osteoclast condition indicated the release of Mg 2+ and Ca 2+ . It is suggested that LC -β-TCP fabricated by the given method could be useful material for bone regeneration because it has both low crystallinity and suitable Ca 2+ and Mg 2+ releasing and most importantly it does not contain any extended protocol.",
author = "Garima Tripathi and Kunio Ishikawa",
year = "2019",
month = "8",
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doi = "10.1016/j.msec.2019.03.106",
language = "English",
volume = "101",
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journal = "Materials Science and Engineering C",
issn = "0928-4931",
publisher = "Elsevier BV",

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AU - Tripathi, Garima

AU - Ishikawa, Kunio

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N2 - Magnesium substituted low crystalline β‑tricalcium phosphates (LC-β-TCP) is an attractive biomaterials owing to its high initial osteoconductivity and bone regeneration. The present investigation is focused on fabrication of low crystalline β-TCP (LC-β-TCP) and evaluating in vitro dissolution toward to the crystallinity of the LC-β-TCP. It is suggested that the crystallinity of biocompatible ceramics greatly affect into their biocompatibility. The novelty of the work is the preparation of the LC-β-TCP without any calcium carbonate/phosphate complex, which is commonly in use. LC-β-TCP was fabricated from MgHPO 4 ·3H 2 O (MgP) and CaCl 2 aqueous solution at 200 °C hydrothermal condition. In vitro dissolution evaluations simulated osteoclast condition indicated the release of Mg 2+ and Ca 2+ . It is suggested that LC -β-TCP fabricated by the given method could be useful material for bone regeneration because it has both low crystallinity and suitable Ca 2+ and Mg 2+ releasing and most importantly it does not contain any extended protocol.

AB - Magnesium substituted low crystalline β‑tricalcium phosphates (LC-β-TCP) is an attractive biomaterials owing to its high initial osteoconductivity and bone regeneration. The present investigation is focused on fabrication of low crystalline β-TCP (LC-β-TCP) and evaluating in vitro dissolution toward to the crystallinity of the LC-β-TCP. It is suggested that the crystallinity of biocompatible ceramics greatly affect into their biocompatibility. The novelty of the work is the preparation of the LC-β-TCP without any calcium carbonate/phosphate complex, which is commonly in use. LC-β-TCP was fabricated from MgHPO 4 ·3H 2 O (MgP) and CaCl 2 aqueous solution at 200 °C hydrothermal condition. In vitro dissolution evaluations simulated osteoclast condition indicated the release of Mg 2+ and Ca 2+ . It is suggested that LC -β-TCP fabricated by the given method could be useful material for bone regeneration because it has both low crystallinity and suitable Ca 2+ and Mg 2+ releasing and most importantly it does not contain any extended protocol.

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