Fabrication of biodegradable particles for DDS by self-organized precipitation method

Daisuke Ohsato, Takeshi Higuchi, Hiroshi Yabu, Masaru Tanaka, Sadaaki Yamamoto, Masatsugu Shimomura

Research output: Contribution to conferencePaper

Abstract

Recently, we have reported the formation of nano-particles by mixing a poor solvent into a solution of polymer, and then evaporating a good solvent. In this report, nano-particles were prepared from various biodegradable polymers. Average size of the particles was measured by dynamic light scattering spectrophotometer. The particles were observed by Field-Emission Scanning Electron Microscopy. Uniform sized particles were formed. The particle size was controlled ranging from 100 nm to 1000 nm. In the case of Poly(ε- caprolactone)(PCL), the particle size became larger with increasing the concentration of solution, and increasing the volume ratio of a good solvent / a poor solvent. Fabrication of biodegradable particles containing a drug and their concentration of drug in the particles will be reported.

Original languageEnglish
Number of pages1
Publication statusPublished - Dec 1 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

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Fabrication
Particle size
Biodegradable polymers
Spectrophotometers
Dynamic light scattering
Field emission
Scanning electron microscopy
Polymers

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Ohsato, D., Higuchi, T., Yabu, H., Tanaka, M., Yamamoto, S., & Shimomura, M. (2005). Fabrication of biodegradable particles for DDS by self-organized precipitation method. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.

Fabrication of biodegradable particles for DDS by self-organized precipitation method. / Ohsato, Daisuke; Higuchi, Takeshi; Yabu, Hiroshi; Tanaka, Masaru; Yamamoto, Sadaaki; Shimomura, Masatsugu.

2005. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.

Research output: Contribution to conferencePaper

Ohsato, D, Higuchi, T, Yabu, H, Tanaka, M, Yamamoto, S & Shimomura, M 2005, 'Fabrication of biodegradable particles for DDS by self-organized precipitation method' Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan, 5/25/05 - 5/27/05, .
Ohsato D, Higuchi T, Yabu H, Tanaka M, Yamamoto S, Shimomura M. Fabrication of biodegradable particles for DDS by self-organized precipitation method. 2005. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.
Ohsato, Daisuke ; Higuchi, Takeshi ; Yabu, Hiroshi ; Tanaka, Masaru ; Yamamoto, Sadaaki ; Shimomura, Masatsugu. / Fabrication of biodegradable particles for DDS by self-organized precipitation method. Paper presented at 54th SPSJ Annual Meeting 2005, Yokohama, Japan.1 p.
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