Abstract
Biphasic calcium phosphate foam consisting of core αTCP covered with carbonate apatite (CO3Ap) was fabricated based on the compositional transformation by exposing αTCP foam to (NH4) 2HPO4 aqueous solution at 200 °C for 90min in order to understand the effect on bone formation rate and granule remaining ratio. The BCP foam was gently crushed and sieved to prepare foam granular. Bone defects made at the mandible of beagle dog were reconstructed with αTCP, BCP and CO3Ap foam granular. 3 months after surgery, bone reconstruction rate of the BCP and CO3Ap were 159.7±28.6% and 169.0±29.7% whereas those of αTCP and blood clot group were 89.5±14.7% and 85.2±13.2%, respectively, and no further increase was observed at 6 month. On the other hand, granular remaining ratio was 3.0±1.7%, 3.1±1.8%, 6.9±2.0% for BCP, αTCP and CO3Ap foam granular, respectivly. We concluded therefore, BCP foam granular could be an ideal bone substitute since it alllows large porosity, at least similar bone formation ratio to CO3Ap and faster replacement to bone.
| Original language | English |
|---|---|
| Pages (from-to) | 233-236 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 396-398 |
| DOIs | |
| Publication status | Published - Feb 2 2009 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering
Cite this
Fabrication of biphasic calcium phosphate foam granular and its initial evaluation using beagle dogs. / Ishikawa, Kunio; Shimogoryo, Ryouji; Wakae, Hanae; Takeuchi, Akari; Matsuya, Shigeki.
In: Key Engineering Materials, Vol. 396-398, 02.02.2009, p. 233-236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fabrication of biphasic calcium phosphate foam granular and its initial evaluation using beagle dogs
AU - Ishikawa, Kunio
AU - Shimogoryo, Ryouji
AU - Wakae, Hanae
AU - Takeuchi, Akari
AU - Matsuya, Shigeki
PY - 2009/2/2
Y1 - 2009/2/2
N2 - Biphasic calcium phosphate foam consisting of core αTCP covered with carbonate apatite (CO3Ap) was fabricated based on the compositional transformation by exposing αTCP foam to (NH4) 2HPO4 aqueous solution at 200 °C for 90min in order to understand the effect on bone formation rate and granule remaining ratio. The BCP foam was gently crushed and sieved to prepare foam granular. Bone defects made at the mandible of beagle dog were reconstructed with αTCP, BCP and CO3Ap foam granular. 3 months after surgery, bone reconstruction rate of the BCP and CO3Ap were 159.7±28.6% and 169.0±29.7% whereas those of αTCP and blood clot group were 89.5±14.7% and 85.2±13.2%, respectively, and no further increase was observed at 6 month. On the other hand, granular remaining ratio was 3.0±1.7%, 3.1±1.8%, 6.9±2.0% for BCP, αTCP and CO3Ap foam granular, respectivly. We concluded therefore, BCP foam granular could be an ideal bone substitute since it alllows large porosity, at least similar bone formation ratio to CO3Ap and faster replacement to bone.
AB - Biphasic calcium phosphate foam consisting of core αTCP covered with carbonate apatite (CO3Ap) was fabricated based on the compositional transformation by exposing αTCP foam to (NH4) 2HPO4 aqueous solution at 200 °C for 90min in order to understand the effect on bone formation rate and granule remaining ratio. The BCP foam was gently crushed and sieved to prepare foam granular. Bone defects made at the mandible of beagle dog were reconstructed with αTCP, BCP and CO3Ap foam granular. 3 months after surgery, bone reconstruction rate of the BCP and CO3Ap were 159.7±28.6% and 169.0±29.7% whereas those of αTCP and blood clot group were 89.5±14.7% and 85.2±13.2%, respectively, and no further increase was observed at 6 month. On the other hand, granular remaining ratio was 3.0±1.7%, 3.1±1.8%, 6.9±2.0% for BCP, αTCP and CO3Ap foam granular, respectivly. We concluded therefore, BCP foam granular could be an ideal bone substitute since it alllows large porosity, at least similar bone formation ratio to CO3Ap and faster replacement to bone.
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UR - http://www.scopus.com/inward/citedby.url?scp=58849130744&partnerID=8YFLogxK
U2 - 10.4028/0-87849-353-0.233
DO - 10.4028/0-87849-353-0.233
M3 - Article
AN - SCOPUS:58849130744
VL - 396-398
SP - 233
EP - 236
JO - Key Engineering Materials
JF - Key Engineering Materials
SN - 1013-9826
ER -