Fabrication of biphasic calcium phosphate foam granular and its initial evaluation using beagle dogs

Kunio Ishikawa, Ryouji Shimogoryo, Hanae Wakae, Akari Takeuchi, Shigeki Matsuya

Research output: Contribution to journalArticle

Abstract

Biphasic calcium phosphate foam consisting of core αTCP covered with carbonate apatite (CO3Ap) was fabricated based on the compositional transformation by exposing αTCP foam to (NH4) 2HPO4 aqueous solution at 200 °C for 90min in order to understand the effect on bone formation rate and granule remaining ratio. The BCP foam was gently crushed and sieved to prepare foam granular. Bone defects made at the mandible of beagle dog were reconstructed with αTCP, BCP and CO3Ap foam granular. 3 months after surgery, bone reconstruction rate of the BCP and CO3Ap were 159.7±28.6% and 169.0±29.7% whereas those of αTCP and blood clot group were 89.5±14.7% and 85.2±13.2%, respectively, and no further increase was observed at 6 month. On the other hand, granular remaining ratio was 3.0±1.7%, 3.1±1.8%, 6.9±2.0% for BCP, αTCP and CO3Ap foam granular, respectivly. We concluded therefore, BCP foam granular could be an ideal bone substitute since it alllows large porosity, at least similar bone formation ratio to CO3Ap and faster replacement to bone.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalKey Engineering Materials
Volume396-398
DOIs
Publication statusPublished - Feb 2 2009

Fingerprint

Calcium phosphate
Foams
Bone
Fabrication
Bone Substitutes
Apatite
Blood Group Antigens
hydroxyapatite-beta tricalcium phosphate
Surgery
Carbonates
Blood
Porosity
Defects

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Fabrication of biphasic calcium phosphate foam granular and its initial evaluation using beagle dogs. / Ishikawa, Kunio; Shimogoryo, Ryouji; Wakae, Hanae; Takeuchi, Akari; Matsuya, Shigeki.

In: Key Engineering Materials, Vol. 396-398, 02.02.2009, p. 233-236.

Research output: Contribution to journalArticle

Ishikawa, Kunio ; Shimogoryo, Ryouji ; Wakae, Hanae ; Takeuchi, Akari ; Matsuya, Shigeki. / Fabrication of biphasic calcium phosphate foam granular and its initial evaluation using beagle dogs. In: Key Engineering Materials. 2009 ; Vol. 396-398. pp. 233-236.
@article{f1671e65790a4e42a84be2868e1def37,
title = "Fabrication of biphasic calcium phosphate foam granular and its initial evaluation using beagle dogs",
abstract = "Biphasic calcium phosphate foam consisting of core αTCP covered with carbonate apatite (CO3Ap) was fabricated based on the compositional transformation by exposing αTCP foam to (NH4) 2HPO4 aqueous solution at 200 °C for 90min in order to understand the effect on bone formation rate and granule remaining ratio. The BCP foam was gently crushed and sieved to prepare foam granular. Bone defects made at the mandible of beagle dog were reconstructed with αTCP, BCP and CO3Ap foam granular. 3 months after surgery, bone reconstruction rate of the BCP and CO3Ap were 159.7±28.6{\%} and 169.0±29.7{\%} whereas those of αTCP and blood clot group were 89.5±14.7{\%} and 85.2±13.2{\%}, respectively, and no further increase was observed at 6 month. On the other hand, granular remaining ratio was 3.0±1.7{\%}, 3.1±1.8{\%}, 6.9±2.0{\%} for BCP, αTCP and CO3Ap foam granular, respectivly. We concluded therefore, BCP foam granular could be an ideal bone substitute since it alllows large porosity, at least similar bone formation ratio to CO3Ap and faster replacement to bone.",
author = "Kunio Ishikawa and Ryouji Shimogoryo and Hanae Wakae and Akari Takeuchi and Shigeki Matsuya",
year = "2009",
month = "2",
day = "2",
doi = "10.4028/0-87849-353-0.233",
language = "English",
volume = "396-398",
pages = "233--236",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",

}

TY - JOUR

T1 - Fabrication of biphasic calcium phosphate foam granular and its initial evaluation using beagle dogs

AU - Ishikawa, Kunio

AU - Shimogoryo, Ryouji

AU - Wakae, Hanae

AU - Takeuchi, Akari

AU - Matsuya, Shigeki

PY - 2009/2/2

Y1 - 2009/2/2

N2 - Biphasic calcium phosphate foam consisting of core αTCP covered with carbonate apatite (CO3Ap) was fabricated based on the compositional transformation by exposing αTCP foam to (NH4) 2HPO4 aqueous solution at 200 °C for 90min in order to understand the effect on bone formation rate and granule remaining ratio. The BCP foam was gently crushed and sieved to prepare foam granular. Bone defects made at the mandible of beagle dog were reconstructed with αTCP, BCP and CO3Ap foam granular. 3 months after surgery, bone reconstruction rate of the BCP and CO3Ap were 159.7±28.6% and 169.0±29.7% whereas those of αTCP and blood clot group were 89.5±14.7% and 85.2±13.2%, respectively, and no further increase was observed at 6 month. On the other hand, granular remaining ratio was 3.0±1.7%, 3.1±1.8%, 6.9±2.0% for BCP, αTCP and CO3Ap foam granular, respectivly. We concluded therefore, BCP foam granular could be an ideal bone substitute since it alllows large porosity, at least similar bone formation ratio to CO3Ap and faster replacement to bone.

AB - Biphasic calcium phosphate foam consisting of core αTCP covered with carbonate apatite (CO3Ap) was fabricated based on the compositional transformation by exposing αTCP foam to (NH4) 2HPO4 aqueous solution at 200 °C for 90min in order to understand the effect on bone formation rate and granule remaining ratio. The BCP foam was gently crushed and sieved to prepare foam granular. Bone defects made at the mandible of beagle dog were reconstructed with αTCP, BCP and CO3Ap foam granular. 3 months after surgery, bone reconstruction rate of the BCP and CO3Ap were 159.7±28.6% and 169.0±29.7% whereas those of αTCP and blood clot group were 89.5±14.7% and 85.2±13.2%, respectively, and no further increase was observed at 6 month. On the other hand, granular remaining ratio was 3.0±1.7%, 3.1±1.8%, 6.9±2.0% for BCP, αTCP and CO3Ap foam granular, respectivly. We concluded therefore, BCP foam granular could be an ideal bone substitute since it alllows large porosity, at least similar bone formation ratio to CO3Ap and faster replacement to bone.

UR - http://www.scopus.com/inward/record.url?scp=58849130744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849130744&partnerID=8YFLogxK

U2 - 10.4028/0-87849-353-0.233

DO - 10.4028/0-87849-353-0.233

M3 - Article

AN - SCOPUS:58849130744

VL - 396-398

SP - 233

EP - 236

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

ER -