Fabrication of carbonate apatite-PLGA hybrid foam bone substitute

Girlie M. Munar, Melvin L. Munar, Kanji Tsuru, Shigeki Matsuya, Kunio Ishikawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Porous carbonate apatite (CO3AP) foam is a potential bone substitute material since it approximates the morphology and mineral phase of bone. One drawback however, is the poor mechanical properties for sufficient handling. A useful method to improve the mechanical property is by reinforcing it with biodegradable polymer. This study reports the preparation of carbonate apatite-PLGA (CO3AP-PLGA) hybrid foam with improved mechanical strength and osteoconductivity. CO3AP foam was prepared by hydrothermal treatment of α-tricalcium phosphate (αTCP) foam in carbonate solution at 150°C for 24 hours. CO3AP powder was synthesized from vaterite (CaCO3) and disodium hydrogen phosphate (Na2HPO4) aqueous solution at 37°C. The obtained CO3AP powder was mixed with 10wt% PLGA solution then reinforced on CO3AP foam using freeze-vacuum technique. The obtained CO 3AP-PLGA hybrid foam showed interconnecting porous structure with average porosity of 85%. Compressive strength of CO3Ap-PLGA hybrid foam was as high as 0.35 MPa when compared to that of CO3Ap foam at 0.01 MPa. X-ray diffraction and FT-IR showed CO3Ap as the primary mineral phase. In conclusion, CO3AP-PLGA hybrid foam with improved mechanical properties and approximates the mineral composition and morphology of the cancellous bone can be a potential bone substitute or scaffold for tissue engineering.

Original languageEnglish
Title of host publicationAdvances in Bioceramics and Porous Ceramics V - A Collection of Papers Presented at the 36th International Conference on Advanced Ceramics and Composites, ICACC 2012
Pages75-78
Number of pages4
Edition6
Publication statusPublished - Apr 8 2013
EventAdvances in Bioceramics and Porous Ceramics V - 36th International Conference on Advanced Ceramics and Composites, ICACC 2012 - Daytona Beach, FL, United States
Duration: Jan 22 2012Jan 27 2012

Publication series

NameCeramic Engineering and Science Proceedings
Number6
Volume33
ISSN (Print)0196-6219

Other

OtherAdvances in Bioceramics and Porous Ceramics V - 36th International Conference on Advanced Ceramics and Composites, ICACC 2012
CountryUnited States
CityDaytona Beach, FL
Period1/22/121/27/12

Fingerprint

Bone Substitutes
Apatite
Foams
Carbonates
Bone
Fabrication
Minerals
Mechanical properties
Powders
Phosphates
polylactic acid-polyglycolic acid copolymer
carboapatite
Biodegradable polymers
Calcium Carbonate
Bioelectric potentials
Carbon Monoxide
Scaffolds (biology)
Tissue engineering
Compressive strength
Strength of materials

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Materials Chemistry

Cite this

Munar, G. M., Munar, M. L., Tsuru, K., Matsuya, S., & Ishikawa, K. (2013). Fabrication of carbonate apatite-PLGA hybrid foam bone substitute. In Advances in Bioceramics and Porous Ceramics V - A Collection of Papers Presented at the 36th International Conference on Advanced Ceramics and Composites, ICACC 2012 (6 ed., pp. 75-78). (Ceramic Engineering and Science Proceedings; Vol. 33, No. 6).

Fabrication of carbonate apatite-PLGA hybrid foam bone substitute. / Munar, Girlie M.; Munar, Melvin L.; Tsuru, Kanji; Matsuya, Shigeki; Ishikawa, Kunio.

Advances in Bioceramics and Porous Ceramics V - A Collection of Papers Presented at the 36th International Conference on Advanced Ceramics and Composites, ICACC 2012. 6. ed. 2013. p. 75-78 (Ceramic Engineering and Science Proceedings; Vol. 33, No. 6).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Munar, GM, Munar, ML, Tsuru, K, Matsuya, S & Ishikawa, K 2013, Fabrication of carbonate apatite-PLGA hybrid foam bone substitute. in Advances in Bioceramics and Porous Ceramics V - A Collection of Papers Presented at the 36th International Conference on Advanced Ceramics and Composites, ICACC 2012. 6 edn, Ceramic Engineering and Science Proceedings, no. 6, vol. 33, pp. 75-78, Advances in Bioceramics and Porous Ceramics V - 36th International Conference on Advanced Ceramics and Composites, ICACC 2012, Daytona Beach, FL, United States, 1/22/12.
Munar GM, Munar ML, Tsuru K, Matsuya S, Ishikawa K. Fabrication of carbonate apatite-PLGA hybrid foam bone substitute. In Advances in Bioceramics and Porous Ceramics V - A Collection of Papers Presented at the 36th International Conference on Advanced Ceramics and Composites, ICACC 2012. 6 ed. 2013. p. 75-78. (Ceramic Engineering and Science Proceedings; 6).
Munar, Girlie M. ; Munar, Melvin L. ; Tsuru, Kanji ; Matsuya, Shigeki ; Ishikawa, Kunio. / Fabrication of carbonate apatite-PLGA hybrid foam bone substitute. Advances in Bioceramics and Porous Ceramics V - A Collection of Papers Presented at the 36th International Conference on Advanced Ceramics and Composites, ICACC 2012. 6. ed. 2013. pp. 75-78 (Ceramic Engineering and Science Proceedings; 6).
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