Porous carbonate apatite (CO3AP) foam is a potential bone substitute material since it approximates the morphology and mineral phase of bone. One drawback however, is the poor mechanical properties for sufficient handling. A useful method to improve the mechanical property is by reinforcing it with biodegradable polymer. This study reports the preparation of carbonate apatite-PLGA (CO3AP-PLGA) hybrid foam with improved mechanical strength and osteoconductivity. CO3AP foam was prepared by hydrothermal treatment of α-tricalcium phosphate (αTCP) foam in carbonate solution at 150°C for 24 hours. CO3AP powder was synthesized from vaterite (CaCO3) and disodium hydrogen phosphate (Na2HPO4) aqueous solution at 37°C. The obtained CO3AP powder was mixed with 10wt% PLGA solution then reinforced on CO3AP foam using freeze-vacuum technique. The obtained CO 3AP-PLGA hybrid foam showed interconnecting porous structure with average porosity of 85%. Compressive strength of CO3Ap-PLGA hybrid foam was as high as 0.35 MPa when compared to that of CO3Ap foam at 0.01 MPa. X-ray diffraction and FT-IR showed CO3Ap as the primary mineral phase. In conclusion, CO3AP-PLGA hybrid foam with improved mechanical properties and approximates the mineral composition and morphology of the cancellous bone can be a potential bone substitute or scaffold for tissue engineering.