TY - JOUR
T1 - Fabrication of carbonate apatite pseudomorph from highly soluble acidic calcium phosphate salts through carbonation
AU - Sugiura, Yuki
AU - Tsuru, Kanji
AU - Ishikawa, Kunio
N1 - Funding Information:
This study was financially supported in part by the Strategic Promotion of Innovative Research and Development Program, Japan Agency for Medical Research and Development, a Grant-in-Aid for Research Activity Start-up by the Japan Society for the Promotion of Science (JSPS) grant number (15H06488), and Kyushu University Interdisciplinary Programs in Education and Projects in Research Development (P&P), Kyushu University, Japan.
Publisher Copyright:
© 2016 The Ceramic Society of Japan. All rights reserved.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/8
Y1 - 2016/8
N2 - B-type carbonate apatite (CO3Ap) has recently emerged as an attractive bone scaffold material because it exhibits significantly higher osteoconductivity than its hydroxyapatite analogue. Highly soluble acidic calcium phosphate salts, such as calcium hydrogen phosphate dehydrate (DCPD) and monocalcium phosphate monophosphate (MCPM), are typically used as bone cement and easily produce large calcium phosphate crystals. However, few studies have focused on these salts as precursors despite extensive investigations on the production of CO3Ap. In this study, DCPD and MCPM were converted into CO3Ap by hydrothermal treatment in the presence of at least 0.5 mol/L NaHCO3, which acted as a neutralizer and CO32- releaser. The obtained material maintained precursor morphologies and was therefore regarded as a pseudomorph of DCPD and MCPM mesocrystal structures. This synthetic approach is expected to facilitate the fabrication of shape-controlled CO3Ap compacts from DCPD and MCPM.
AB - B-type carbonate apatite (CO3Ap) has recently emerged as an attractive bone scaffold material because it exhibits significantly higher osteoconductivity than its hydroxyapatite analogue. Highly soluble acidic calcium phosphate salts, such as calcium hydrogen phosphate dehydrate (DCPD) and monocalcium phosphate monophosphate (MCPM), are typically used as bone cement and easily produce large calcium phosphate crystals. However, few studies have focused on these salts as precursors despite extensive investigations on the production of CO3Ap. In this study, DCPD and MCPM were converted into CO3Ap by hydrothermal treatment in the presence of at least 0.5 mol/L NaHCO3, which acted as a neutralizer and CO32- releaser. The obtained material maintained precursor morphologies and was therefore regarded as a pseudomorph of DCPD and MCPM mesocrystal structures. This synthetic approach is expected to facilitate the fabrication of shape-controlled CO3Ap compacts from DCPD and MCPM.
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U2 - 10.2109/jcersj2.16046
DO - 10.2109/jcersj2.16046
M3 - Article
AN - SCOPUS:84980347552
SN - 1882-0743
VL - 124
SP - 827
EP - 832
JO - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
JF - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
IS - 8
ER -