Abstract
β-Tricalcium phosphate (β-TCP) has attracted much attention as an artificial bone substitute owing to its biocompatibility and osteoconductivity. In this study, osteoconductivity of β-TCP bone substitute was enhanced without using growth factors or cells. Dicalcium phosphate dihydrate (DCPD), which is known to possess the highest solubility among calcium phosphates, was coated on β-TCP granules by exposing their surface with acidic calcium phosphate solution. The amount of coated DCPD was regulated by changing the reaction time between β-TCP granules and acidic calcium phosphate solution. Histomorphometry analysis obtained from histological results revealed that the approximately 10 mol% DCPD-coated β-TCP granules showed the largest new bone formation compared to DCPD-free β-TCP granules, approximately 2.5 mol% DCPD-coated β-TCP granules, or approximately 27 mol% DCPD-coated β-TCP granules after 2 and 4 weeks of implantation. Based on this finding, we demonstrate that the osteoconductivity of β-TCP granules could be improved by coating their surface with an appropriate amount of DCPD.
| Original language | English |
|---|---|
| Pages (from-to) | 1411-1419 |
| Number of pages | 9 |
| Journal | Materials Science and Engineering C |
| Volume | 75 |
| DOIs | |
| Publication status | Published - Jun 1 2017 |
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics
- Mechanics of Materials
- Mechanical Engineering
Cite this
Fabrication of dicalcium phosphate dihydrate-coated β-TCP granules and evaluation of their osteoconductivity using experimental rats. / Shariff, Khairul Anuar; Tsuru, Kanji; Ishikawa, Kunio.
In: Materials Science and Engineering C, Vol. 75, 01.06.2017, p. 1411-1419.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fabrication of dicalcium phosphate dihydrate-coated β-TCP granules and evaluation of their osteoconductivity using experimental rats
AU - Shariff, Khairul Anuar
AU - Tsuru, Kanji
AU - Ishikawa, Kunio
PY - 2017/6/1
Y1 - 2017/6/1
N2 - β-Tricalcium phosphate (β-TCP) has attracted much attention as an artificial bone substitute owing to its biocompatibility and osteoconductivity. In this study, osteoconductivity of β-TCP bone substitute was enhanced without using growth factors or cells. Dicalcium phosphate dihydrate (DCPD), which is known to possess the highest solubility among calcium phosphates, was coated on β-TCP granules by exposing their surface with acidic calcium phosphate solution. The amount of coated DCPD was regulated by changing the reaction time between β-TCP granules and acidic calcium phosphate solution. Histomorphometry analysis obtained from histological results revealed that the approximately 10 mol% DCPD-coated β-TCP granules showed the largest new bone formation compared to DCPD-free β-TCP granules, approximately 2.5 mol% DCPD-coated β-TCP granules, or approximately 27 mol% DCPD-coated β-TCP granules after 2 and 4 weeks of implantation. Based on this finding, we demonstrate that the osteoconductivity of β-TCP granules could be improved by coating their surface with an appropriate amount of DCPD.
AB - β-Tricalcium phosphate (β-TCP) has attracted much attention as an artificial bone substitute owing to its biocompatibility and osteoconductivity. In this study, osteoconductivity of β-TCP bone substitute was enhanced without using growth factors or cells. Dicalcium phosphate dihydrate (DCPD), which is known to possess the highest solubility among calcium phosphates, was coated on β-TCP granules by exposing their surface with acidic calcium phosphate solution. The amount of coated DCPD was regulated by changing the reaction time between β-TCP granules and acidic calcium phosphate solution. Histomorphometry analysis obtained from histological results revealed that the approximately 10 mol% DCPD-coated β-TCP granules showed the largest new bone formation compared to DCPD-free β-TCP granules, approximately 2.5 mol% DCPD-coated β-TCP granules, or approximately 27 mol% DCPD-coated β-TCP granules after 2 and 4 weeks of implantation. Based on this finding, we demonstrate that the osteoconductivity of β-TCP granules could be improved by coating their surface with an appropriate amount of DCPD.
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U2 - 10.1016/j.msec.2017.03.004
DO - 10.1016/j.msec.2017.03.004
M3 - Article
C2 - 28415432
AN - SCOPUS:85015668509
VL - 75
SP - 1411
EP - 1419
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
SN - 0928-4931
ER -