Fabrication of glucose-sensitive TiO2 ultrathin films by molecular imprinting and selective detection of monosaccharides

Do Hyeon Yang, Naoki Takahara, Seung Woo Lee, Toyoki Kunitake

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


In this study, we extended the molecular imprinting capability of TiO2 gel to the monosaccharide family. Composite nanofilms were prepared from d-glucose and titanium n-butoxide, Ti(O-nBu)4, on a QCM electrode by the surface sol-gel process. After the d-glucose template was removed, the binding behavior of the template and other monosaccharides (d-mannose, d-galactose and d-fructose) was examined by QCM measurement The d-glucose imprinted TiO2 gel film provided sensitively mass increases for monosaccharides. The largest binding was achieved with d-glucose, showing a maximal binding ratio of 2.3 (λ = Mimp/Mnon-imp, mol/mol) between the imprinted and non-imprinted films. The other six-membered monosaccharide guests gave 44-68% binding efficiencies of that of d-glucose. It is concluded that the imprinted TiO2 gel film could efficiently discriminate the structure of monosaccharide isomers.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalSensors and Actuators, B: Chemical
Issue number1
Publication statusPublished - Mar 14 2008

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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