Fabrication of glucose-sensitive TiO2 ultrathin films by molecular imprinting and selective detection of monosaccharides

Do Hyeon Yang, Naoki Takahara, Seung Woo Lee, Toyoki Kunitake

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

In this study, we extended the molecular imprinting capability of TiO2 gel to the monosaccharide family. Composite nanofilms were prepared from d-glucose and titanium n-butoxide, Ti(O-nBu)4, on a QCM electrode by the surface sol-gel process. After the d-glucose template was removed, the binding behavior of the template and other monosaccharides (d-mannose, d-galactose and d-fructose) was examined by QCM measurement The d-glucose imprinted TiO2 gel film provided sensitively mass increases for monosaccharides. The largest binding was achieved with d-glucose, showing a maximal binding ratio of 2.3 (λ = Mimp/Mnon-imp, mol/mol) between the imprinted and non-imprinted films. The other six-membered monosaccharide guests gave 44-68% binding efficiencies of that of d-glucose. It is concluded that the imprinted TiO2 gel film could efficiently discriminate the structure of monosaccharide isomers.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalSensors and Actuators, B: Chemical
Volume130
Issue number1
DOIs
Publication statusPublished - Mar 14 2008

Fingerprint

monosaccharides
Monosaccharides
Ultrathin films
glucose
Glucose
Fabrication
fabrication
Gels
gels
templates
galactose
Fructose
sol-gel processes
Mannose
Titanium
Galactose
Isomers
Sol-gel process
isomers
titanium

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

Fabrication of glucose-sensitive TiO2 ultrathin films by molecular imprinting and selective detection of monosaccharides. / Yang, Do Hyeon; Takahara, Naoki; Lee, Seung Woo; Kunitake, Toyoki.

In: Sensors and Actuators, B: Chemical, Vol. 130, No. 1, 14.03.2008, p. 379-385.

Research output: Contribution to journalArticle

Yang, Do Hyeon ; Takahara, Naoki ; Lee, Seung Woo ; Kunitake, Toyoki. / Fabrication of glucose-sensitive TiO2 ultrathin films by molecular imprinting and selective detection of monosaccharides. In: Sensors and Actuators, B: Chemical. 2008 ; Vol. 130, No. 1. pp. 379-385.
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