TY - JOUR
T1 - Fabrication of interconnected pore forming α-tricalcium phosphate foam granules cement
AU - Shariff, Khairul Anuar
AU - Tsuru, Kanji
AU - Ishikawa, Kunio
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported in part by the Strategic Promotion of Innovative Research and Development Program of the Japan Agency for Medical Research and Development and Grants-in-Aid for Scientific Research from the Japanese Society for Promotion of Science and Research. The first author would like to thank AUN/SEED-Net, JICA, Universiti Sains Malaysia (USM), and the Ministry of Education Malaysia for their financial support to study in Japan.
Publisher Copyright:
© SAGE Publications.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Interconnected pore forming calcium phosphate cement is useful for the reconstruction of bone defects as well as scaffold fabrication in tissue engineering. In this study, interconnected pore forming calcium phosphate cement was fabricated using α-tricalcium phosphate (α-TCP) foam granules. When α-TCP foam granules were mixed with acidic calcium phosphate solution prepared from monocalcium phosphate monohydrate (MCPM) and phosphoric acid solution, brushite crystals were precipitated. These crystals bridged the α-TCP foam granules immediately upon mixing. As a result of the brushite bridge between the α-TCP foam granules, fully interconnected macroporous α-TCP was obtained. The amount of brushite precipitate and the mechanical strength of the set cement increased with acidic calcium phosphate concentration.
AB - Interconnected pore forming calcium phosphate cement is useful for the reconstruction of bone defects as well as scaffold fabrication in tissue engineering. In this study, interconnected pore forming calcium phosphate cement was fabricated using α-tricalcium phosphate (α-TCP) foam granules. When α-TCP foam granules were mixed with acidic calcium phosphate solution prepared from monocalcium phosphate monohydrate (MCPM) and phosphoric acid solution, brushite crystals were precipitated. These crystals bridged the α-TCP foam granules immediately upon mixing. As a result of the brushite bridge between the α-TCP foam granules, fully interconnected macroporous α-TCP was obtained. The amount of brushite precipitate and the mechanical strength of the set cement increased with acidic calcium phosphate concentration.
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U2 - 10.1177/0885328215601939
DO - 10.1177/0885328215601939
M3 - Article
C2 - 26329353
AN - SCOPUS:84954285621
VL - 30
SP - 838
EP - 845
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
SN - 0885-3282
IS - 6
ER -