Fabrication of interconnected pore forming α-tricalcium phosphate foam granules cement

Khairul Anuar Shariff, Kanji Tsuru, Kunio Ishikawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Interconnected pore forming calcium phosphate cement is useful for the reconstruction of bone defects as well as scaffold fabrication in tissue engineering. In this study, interconnected pore forming calcium phosphate cement was fabricated using α-tricalcium phosphate (α-TCP) foam granules. When α-TCP foam granules were mixed with acidic calcium phosphate solution prepared from monocalcium phosphate monohydrate (MCPM) and phosphoric acid solution, brushite crystals were precipitated. These crystals bridged the α-TCP foam granules immediately upon mixing. As a result of the brushite bridge between the α-TCP foam granules, fully interconnected macroporous α-TCP was obtained. The amount of brushite precipitate and the mechanical strength of the set cement increased with acidic calcium phosphate concentration.

Original languageEnglish
Pages (from-to)838-845
Number of pages8
JournalJournal of Biomaterials Applications
Volume30
Issue number6
DOIs
Publication statusPublished - Jan 1 2016

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Calcium phosphate
Foams
Cements
Phosphates
Fabrication
Bone cement
Crystals
Phosphoric acid
Scaffolds (biology)
Tissue engineering
Strength of materials
Precipitates
Bone
Defects
tricalcium phosphate
calcium phosphate
dibasic calcium phosphate dihydrate

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Fabrication of interconnected pore forming α-tricalcium phosphate foam granules cement. / Shariff, Khairul Anuar; Tsuru, Kanji; Ishikawa, Kunio.

In: Journal of Biomaterials Applications, Vol. 30, No. 6, 01.01.2016, p. 838-845.

Research output: Contribution to journalArticle

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