Fabrication of interconnected porous β-tricalcium phosphate (β-TCP) based on a setting reaction of β-TCP granules with HNO3 followed by heat treatment

Kunio Ishikawa, Tansza Setiana Putri, Akira Tsuchiya, Keisuke Tanaka, Kanji Tsuru

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2 Citations (Scopus)


β-Tricalcium phosphate [β-TCP] is the typical bone substitute due to its excellent osteoconductivity and bioresorbability. One of the keys to improve its potential as bone substitute is to introduce porous structure and its regulation. In this study, interconnected porous β-TCP blocks were fabricated through a setting reaction of β-TCP granules and subsequent heat treatment. First, β-TCP granules were mixed with HNO3. Upon mixing, β-TCP granules were bridged with dicalcium phosphate dihydrate [DCPD: CaHPO4·2H2O] containing Ca(NO3)2. Then, the DCPD-bridged β-TCP was heated at 1100°C. During the heating process, DCPD containing Ca(NO3)2 transformed into β-TCP and bonded with β-TCP granules. As a result, an interconnected porous β-TCP block formed. The diametral tensile strength and porosity of the interconnected porous β-TCP block fabricated from 200–300-μm β-TCP granules and 5 N HNO3 and then heated at 1,100°C were 1.4 ± 0.2 MPa and 57% ± 2%, respectively.

Original languageEnglish
Pages (from-to)797-804
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Issue number3
Publication statusPublished - Mar 2018


All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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