Fabrication of interconnected porous calcium-deficient hydroxyapatite using the setting reaction of α tricalcium phosphate spherical granules

Tya Indah Arifta, Melvin L. Munar, Kanji Tsuru, Kunio Ishikawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Interconnected porous calcium-deficient hydroxyapatite (cdHAp) blocks may be an ideal biomaterial to repair bone defects because of their greater similarity to human bone than that of sintered hydroxyapatite (HAp) with respect to calcium content and crystallinity. In particular, the interconnected pores in cdHAp may provide pathways for cell migration and tissue ingrowth. In this study, the feasibility of fabricating interconnected porous cdHAp blocks through the setting reaction of alpha-tricalcium phosphate (αTCP) spherical granules was investigated. It was found that regulation of cdHAp formation was important to fabricate interconnected porous cdHAp blocks. That is, cdHAp needed to precipitate preferentially at the contacting areas between αTCP spherical granules. Exposure of αTCP spherical granules to steam under appropriate pressure was effective for this purpose. When αTCP spherical granules were immersed in water at 100 °C, the setting reaction resulted in dense cdHAp blocks because of the free crystal growth of cdHAp in water. Therefore, steam was used to localize the water at the contacting areas between αTCP spherical granules, which was driven by the surface tension of the water. Without an applied load, no setting reaction was observed when αTCP spherical granules were exposed to steam at 100 °C for 12 h. In contrast, under a load of 20 MPa, cdHAp precipitated to bridge spherical granules, providing an interconnected porous cdHAp block. The porosity and diametral tensile strength of this block were approximately 63% and 1.5 MPa, respectively.

Original languageEnglish
Pages (from-to)11149-11155
Number of pages7
JournalCeramics International
Volume43
Issue number14
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Durapatite
Hydroxyapatite
Calcium
Phosphates
Fabrication
Steam
Water
Bone
tricalcium phosphate
Biocompatible Materials
Crystallization
Crystal growth
Biomaterials
Surface tension
Precipitates
Repair
Tensile strength
Porosity
Tissue
Defects

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Fabrication of interconnected porous calcium-deficient hydroxyapatite using the setting reaction of α tricalcium phosphate spherical granules. / Arifta, Tya Indah; Munar, Melvin L.; Tsuru, Kanji; Ishikawa, Kunio.

In: Ceramics International, Vol. 43, No. 14, 01.10.2017, p. 11149-11155.

Research output: Contribution to journalArticle

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