Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor

Yuki Sugiura, Melvin L. Munar, Kunio Ishikawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5% and, 69.0 ± 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.

Original languageEnglish
Article number151
JournalJournal of Materials Science: Materials in Medicine
Volume29
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

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Calcium Sulfate
Calcium
Dissolution
Phosphates
Fabrication
Bone
Bone and Bones
Bone Substitutes
octacalcium phosphate
Sulfates
Microporosity
Tensile Strength
Durapatite
Gelatin
Powders
Hydroxyapatite
Collagen
Tensile strength
Salts

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

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title = "Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor",
abstract = "Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5{\%} and, 69.0 ± 1.6{\%}, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30{\%} of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.",
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