Fabrication of octacalcium phosphate foam through phase conversion and its histological evaluation

Yuki Sugiura, Melvin L. Munar, Kunio Ishikawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Octacalcium phosphate (OCP) foam with an interconnected porous structure was fabricated through phase conversion via a dissolution–precipitation reaction using calcium sulfate hemihydrate (CSH: CaSO4·1/2H2O) granules as precursors in a sodium dihydrogen phosphate (NaDP: NaH2PO4) solution. The diametral tensile strength and porosity of the OCP foam were 0.15 ± 0.04 MPa and 69.4% ± 0.04%, respectively. When the OCP foam was implanted into bone defects in a rabbit femur, the OCP foam showed an excellent tissue response, and the bone penetrated into the porous structure. The osteoconductivity and bone-replacement rate were significantly higher than those of an OCP compact.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalMaterials Letters
Volume212
DOIs
Publication statusPublished - Feb 1 2018

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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