Fabrication of porous calcite using chopped nylon fiber and its evaluation using rats

Kunio Ishikawa, Nguyen Xuan Thanh Tram, Kanji Tsuru, Riki Toita

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Although porous calcite has attracted attention as bone substitutes, limited studies have been made so far. In the present study, porous calcite block was fabricated by introducing chopped nylon fiber as porogen. Ca(OH)2 powder containing 10 wt% chopped nylon fiber was compacted at 150 MPa, and sintered to burn out the fiber and to carbonate the Ca(OH)2 under stream of 1:2 O2–CO2. Sintering of Ca(OH)2 at 750 °C or lower temperature resulted in incomplete burning out of the fiber whereas sintering at 800 °C or higher temperature resulted in the formation of CaO due to the thermal decomposition of Ca(OH)2. However, sintering at 770 °C resulted in complete burning out of the fiber and complete carbonation of Ca(OH)2 to calcite without forming CaO. Macro- and micro-porosities of the porous calcite were approximately 23 and 16 %, respectively. Diameter of the macropores was approximately 100 μm which is suitable for bone tissue penetration. Porous calcite block fabricated by this method exhibited good tissue response when implanted in the bone defect in femur of 12-weeks-old rat. Four weeks after implantation, bone bonded on the surface of calcite. Furthermore, bone tissue penetrated interior to the macropore at 8 weeks. These results demonstrated the good potential value of porous calcite as artificial bone substitutes.

Original languageEnglish
JournalJournal of Materials Science: Materials in Medicine
Volume26
Issue number2
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Calcium Carbonate
Nylons
Calcite
Rats
Bone
Fabrication
Fibers
Bone Substitutes
Bone and Bones
Sintering
Porosity
Tissue
Microporosity
Temperature
Carbonation
Carbonates
Powders
Femur
Macros
Pyrolysis

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biophysics
  • Biomaterials
  • Biomedical Engineering

Cite this

Fabrication of porous calcite using chopped nylon fiber and its evaluation using rats. / Ishikawa, Kunio; Tram, Nguyen Xuan Thanh; Tsuru, Kanji; Toita, Riki.

In: Journal of Materials Science: Materials in Medicine, Vol. 26, No. 2, 01.01.2015.

Research output: Contribution to journalArticle

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