Fabrication of porous chitosan/hydroxyapatite nanocomposites

Their mechanical and biological properties

Haruhiko Kashiwazaki, Yusuke Kishiya, Atsushi Matsuda, Keisuke Yamaguchi, Tadashi Iizuka, Junzo Tanaka, Nobuo Inoue

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We fabricated novel chitosan/hydroxyapatite (HAp) nanocomposites with porous structure by the co-precipitation and porogen leaching method. SEM observation confirmed that the porous chitosan/HAp nanocomposites with 60.6% and 87.1% porosity showed the interconnective pores with pore diameters in the range of 100-200 μm. The composites were found to be mechanically flexible and could be easily formed into any desired shape. The mechanical strength was enhanced by the heat treatment with saturated steam, which was ascribed to the formation of hydrogen bonds between chitosan molecules. The composites subcutaneously implanted in the backs of SD rats for 3 weeks caused little inflammation, and new blood vessel growth and giant cells were found around the composite accompanied with roughening of the surface due to degradation, showing good biocompatibility and biodegradation.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalBio-Medical Materials and Engineering
Volume19
Issue number2-3
DOIs
Publication statusPublished - Jul 27 2009
Externally publishedYes

Fingerprint

Chitosan
Durapatite
Hydroxyapatite
Nanocomposites
Fabrication
Composite materials
Steam
Blood vessels
Coprecipitation
Biodegradation
Biocompatibility
Leaching
Strength of materials
Rats
Hydrogen bonds
Porosity
Heat treatment
Degradation
Scanning electron microscopy
Molecules

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Fabrication of porous chitosan/hydroxyapatite nanocomposites : Their mechanical and biological properties. / Kashiwazaki, Haruhiko; Kishiya, Yusuke; Matsuda, Atsushi; Yamaguchi, Keisuke; Iizuka, Tadashi; Tanaka, Junzo; Inoue, Nobuo.

In: Bio-Medical Materials and Engineering, Vol. 19, No. 2-3, 27.07.2009, p. 133-140.

Research output: Contribution to journalArticle

Kashiwazaki, Haruhiko ; Kishiya, Yusuke ; Matsuda, Atsushi ; Yamaguchi, Keisuke ; Iizuka, Tadashi ; Tanaka, Junzo ; Inoue, Nobuo. / Fabrication of porous chitosan/hydroxyapatite nanocomposites : Their mechanical and biological properties. In: Bio-Medical Materials and Engineering. 2009 ; Vol. 19, No. 2-3. pp. 133-140.
@article{06287942171b4cf5aa202641df2368fa,
title = "Fabrication of porous chitosan/hydroxyapatite nanocomposites: Their mechanical and biological properties",
abstract = "We fabricated novel chitosan/hydroxyapatite (HAp) nanocomposites with porous structure by the co-precipitation and porogen leaching method. SEM observation confirmed that the porous chitosan/HAp nanocomposites with 60.6{\%} and 87.1{\%} porosity showed the interconnective pores with pore diameters in the range of 100-200 μm. The composites were found to be mechanically flexible and could be easily formed into any desired shape. The mechanical strength was enhanced by the heat treatment with saturated steam, which was ascribed to the formation of hydrogen bonds between chitosan molecules. The composites subcutaneously implanted in the backs of SD rats for 3 weeks caused little inflammation, and new blood vessel growth and giant cells were found around the composite accompanied with roughening of the surface due to degradation, showing good biocompatibility and biodegradation.",
author = "Haruhiko Kashiwazaki and Yusuke Kishiya and Atsushi Matsuda and Keisuke Yamaguchi and Tadashi Iizuka and Junzo Tanaka and Nobuo Inoue",
year = "2009",
month = "7",
day = "27",
doi = "10.3233/BME-2009-0572",
language = "English",
volume = "19",
pages = "133--140",
journal = "Bio-Medical Materials and Engineering",
issn = "0959-2989",
publisher = "IOS Press",
number = "2-3",

}

TY - JOUR

T1 - Fabrication of porous chitosan/hydroxyapatite nanocomposites

T2 - Their mechanical and biological properties

AU - Kashiwazaki, Haruhiko

AU - Kishiya, Yusuke

AU - Matsuda, Atsushi

AU - Yamaguchi, Keisuke

AU - Iizuka, Tadashi

AU - Tanaka, Junzo

AU - Inoue, Nobuo

PY - 2009/7/27

Y1 - 2009/7/27

N2 - We fabricated novel chitosan/hydroxyapatite (HAp) nanocomposites with porous structure by the co-precipitation and porogen leaching method. SEM observation confirmed that the porous chitosan/HAp nanocomposites with 60.6% and 87.1% porosity showed the interconnective pores with pore diameters in the range of 100-200 μm. The composites were found to be mechanically flexible and could be easily formed into any desired shape. The mechanical strength was enhanced by the heat treatment with saturated steam, which was ascribed to the formation of hydrogen bonds between chitosan molecules. The composites subcutaneously implanted in the backs of SD rats for 3 weeks caused little inflammation, and new blood vessel growth and giant cells were found around the composite accompanied with roughening of the surface due to degradation, showing good biocompatibility and biodegradation.

AB - We fabricated novel chitosan/hydroxyapatite (HAp) nanocomposites with porous structure by the co-precipitation and porogen leaching method. SEM observation confirmed that the porous chitosan/HAp nanocomposites with 60.6% and 87.1% porosity showed the interconnective pores with pore diameters in the range of 100-200 μm. The composites were found to be mechanically flexible and could be easily formed into any desired shape. The mechanical strength was enhanced by the heat treatment with saturated steam, which was ascribed to the formation of hydrogen bonds between chitosan molecules. The composites subcutaneously implanted in the backs of SD rats for 3 weeks caused little inflammation, and new blood vessel growth and giant cells were found around the composite accompanied with roughening of the surface due to degradation, showing good biocompatibility and biodegradation.

UR - http://www.scopus.com/inward/record.url?scp=67650863173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650863173&partnerID=8YFLogxK

U2 - 10.3233/BME-2009-0572

DO - 10.3233/BME-2009-0572

M3 - Article

VL - 19

SP - 133

EP - 140

JO - Bio-Medical Materials and Engineering

JF - Bio-Medical Materials and Engineering

SN - 0959-2989

IS - 2-3

ER -