TY - JOUR
T1 - Fabrication of porous chitosan/hydroxyapatite nanocomposites
T2 - Their mechanical and biological properties
AU - Kashiwazaki, Haruhiko
AU - Kishiya, Yusuke
AU - Matsuda, Atsushi
AU - Yamaguchi, Keisuke
AU - Iizuka, Tadashi
AU - Tanaka, Junzo
AU - Inoue, Nobuo
PY - 2009/7/27
Y1 - 2009/7/27
N2 - We fabricated novel chitosan/hydroxyapatite (HAp) nanocomposites with porous structure by the co-precipitation and porogen leaching method. SEM observation confirmed that the porous chitosan/HAp nanocomposites with 60.6% and 87.1% porosity showed the interconnective pores with pore diameters in the range of 100-200 μm. The composites were found to be mechanically flexible and could be easily formed into any desired shape. The mechanical strength was enhanced by the heat treatment with saturated steam, which was ascribed to the formation of hydrogen bonds between chitosan molecules. The composites subcutaneously implanted in the backs of SD rats for 3 weeks caused little inflammation, and new blood vessel growth and giant cells were found around the composite accompanied with roughening of the surface due to degradation, showing good biocompatibility and biodegradation.
AB - We fabricated novel chitosan/hydroxyapatite (HAp) nanocomposites with porous structure by the co-precipitation and porogen leaching method. SEM observation confirmed that the porous chitosan/HAp nanocomposites with 60.6% and 87.1% porosity showed the interconnective pores with pore diameters in the range of 100-200 μm. The composites were found to be mechanically flexible and could be easily formed into any desired shape. The mechanical strength was enhanced by the heat treatment with saturated steam, which was ascribed to the formation of hydrogen bonds between chitosan molecules. The composites subcutaneously implanted in the backs of SD rats for 3 weeks caused little inflammation, and new blood vessel growth and giant cells were found around the composite accompanied with roughening of the surface due to degradation, showing good biocompatibility and biodegradation.
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U2 - 10.3233/BME-2009-0572
DO - 10.3233/BME-2009-0572
M3 - Article
C2 - 19581706
AN - SCOPUS:67650863173
SN - 0959-2989
VL - 19
SP - 133
EP - 140
JO - Bio-Medical Materials and Engineering
JF - Bio-Medical Materials and Engineering
IS - 2-3
ER -