Fabrication of self-setting β-TCP granular cement using β-TCP granules and sodium hydrogen sulfate solution

Eddy, Akira Tsuchiya, Kanji Tsuru, Kunio Ishikawa

Research output: Contribution to journalArticle

Abstract

Bridging beta-tricalcium phosphate (β-TCP) granules with dicalcium phosphate dihydrate (DCPD) creates a porous, interconnected β-TCP granular cement (GC) that is useful for reconstructing bone defects: the interconnected pores can accelerate new bone ingrowth and the set cement prevents the loss of granules from the bone defect area. However, the setting time of β-TCP GC in an acidic calcium phosphate solution is too short (<1 min) for handling in clinical applications, such as in orthopedic surgery. To address this issue, we sought to optimize the setting time of β-TCP GC using β-TCP granules and NaHSO4 solution, as (Formula presented.) is a known inhibitor of DCPD formation. Both DCPD and calcium sulfate dihydrate (CSD) precipitated on the surface of β-TCP granules and bridged β-TCP granules to one another. Increasing NaHSO4 concentration (from 0.5 mol/L to 5 mol/L) led to an increase in the amount of precipitant from 2.6 ± 0.2% to 21.6 ± 1.3% for DCPD and 1.3 ± 0.3% to 10.1 ± 0.5% for CSD. The diametral tensile strength was also increased from 0.03 ± 0.01 MPa to 2.0 ± 0.1 MPa with increasing NaHSO4 concentration. When 2 mol/L NaHSO4 solution was used as the liquid phase, setting time became 5.3 ± 0.2 min, which is suitable for handling in clinical applications to repair bone defects. In conclusion, β-TCP GC using NaHSO4 solution as the liquid phase has good potential value as bone augmentation cement.

Original languageEnglish
Pages (from-to)630-636
Number of pages7
JournalJournal of Biomaterials Applications
Volume33
Issue number5
DOIs
Publication statusPublished - Nov 1 2018

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Bone cement
Sulfates
Hydrogen
Bone
Cements
Phosphates
Sodium
Calcium Sulfate
Fabrication
Defects
Calcium
Bone Cements
Orthopedics
Liquids
Surgery
Calcium phosphate
Repair
Tensile strength
dibasic calcium phosphate dihydrate

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Fabrication of self-setting β-TCP granular cement using β-TCP granules and sodium hydrogen sulfate solution. / Eddy, ; Tsuchiya, Akira; Tsuru, Kanji; Ishikawa, Kunio.

In: Journal of Biomaterials Applications, Vol. 33, No. 5, 01.11.2018, p. 630-636.

Research output: Contribution to journalArticle

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