Fabry disease exhibiting recurrent stroke and persistent inflammation

Yoko Kikumoto; Yasufumi Kai; Hiroshi Morinaga; Mutsunori Iga-Murahashi; Mikitaro Matsuyama; Takashi Sasaki; Hiroki Maruyama; Masaaki Shimotori; Hirofumi Makino; Hitoshi Sugiyama; Akihiko Okayama

doi:10.2169/internalmedicine.49.3724

Fabry disease exhibiting recurrent stroke and persistent inflammation

Yoko Kikumoto, Yasufumi Kai, Hiroshi Morinaga, Mutsunori Iga-Murahashi, Mikitaro Matsuyama, Takashi Sasaki, Hiroki Maruyama, Masaaki Shimotori, Hirofumi Makino, Hitoshi Sugiyama, Akihiko Okayama

Department of Advanced Molecular and Cell Therapy

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We describe two cases of Fabry disease in non-blood-related Japanese men, manifesting recurrent stroke even after the start of enzyme replacement therapy. Both exhibited chronic inflammation and ocular involvement with elevated levels of serum C reactive protein prior to the onset of stroke. We, therefore, suggest the association among persistent inflammation, ocular involvement and recurrent stroke in a certain subset of Fabry disease patients. Both cases received enzyme replacement therapy with no improvement in inflammatory signs or laboratory data. These cases suggest that Fabry disease should be considered in young patients with cryptogenic stroke or CNS manifestations and fever of unknown origin.

Original language	English
Pages (from-to)	2247-2252
Number of pages	6
Journal	Internal Medicine
Volume	49
Issue number	20
DOIs	https://doi.org/10.2169/internalmedicine.49.3724
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Internal Medicine

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Fabry disease exhibiting recurrent stroke and persistent inflammation. / Kikumoto, Yoko; Kai, Yasufumi; Morinaga, Hiroshi; Iga-Murahashi, Mutsunori; Matsuyama, Mikitaro; Sasaki, Takashi; Maruyama, Hiroki; Shimotori, Masaaki; Makino, Hirofumi; Sugiyama, Hitoshi; Okayama, Akihiko.

In: Internal Medicine, Vol. 49, No. 20, 2010, p. 2247-2252.

Research output: Contribution to journal › Article › peer-review

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AU - Sasaki, Takashi

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AU - Makino, Hirofumi

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