TY - JOUR
T1 - Fabry disease exhibiting recurrent stroke and persistent inflammation
AU - Kikumoto, Yoko
AU - Kai, Yasufumi
AU - Morinaga, Hiroshi
AU - Iga-Murahashi, Mutsunori
AU - Matsuyama, Mikitaro
AU - Sasaki, Takashi
AU - Maruyama, Hiroki
AU - Shimotori, Masaaki
AU - Makino, Hirofumi
AU - Sugiyama, Hitoshi
AU - Okayama, Akihiko
PY - 2010
Y1 - 2010
N2 - We describe two cases of Fabry disease in non-blood-related Japanese men, manifesting recurrent stroke even after the start of enzyme replacement therapy. Both exhibited chronic inflammation and ocular involvement with elevated levels of serum C reactive protein prior to the onset of stroke. We, therefore, suggest the association among persistent inflammation, ocular involvement and recurrent stroke in a certain subset of Fabry disease patients. Both cases received enzyme replacement therapy with no improvement in inflammatory signs or laboratory data. These cases suggest that Fabry disease should be considered in young patients with cryptogenic stroke or CNS manifestations and fever of unknown origin.
AB - We describe two cases of Fabry disease in non-blood-related Japanese men, manifesting recurrent stroke even after the start of enzyme replacement therapy. Both exhibited chronic inflammation and ocular involvement with elevated levels of serum C reactive protein prior to the onset of stroke. We, therefore, suggest the association among persistent inflammation, ocular involvement and recurrent stroke in a certain subset of Fabry disease patients. Both cases received enzyme replacement therapy with no improvement in inflammatory signs or laboratory data. These cases suggest that Fabry disease should be considered in young patients with cryptogenic stroke or CNS manifestations and fever of unknown origin.
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U2 - 10.2169/internalmedicine.49.3724
DO - 10.2169/internalmedicine.49.3724
M3 - Article
C2 - 20962444
AN - SCOPUS:78449306112
VL - 49
SP - 2247
EP - 2252
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 20
ER -