Abstract
We report the first non-Caucasian case of facial onset sensory and motor neuronopathy (FOSMN) syndrome partially responding to various immunotherapies. A 55-year-old man had first felt paresthesia on his right cheek at age 45. This gradually extended to the scalp. Paresthesia of bilateral fingers and dysphagia appeared 6 years later. On admission, facial sensory impairment and bulbar palsy were found. There were no sensory or motor deficits evident in any limb, except for decreased deep tendon reflex and vibratory sensation. Videofluorography (VF) revealed decreased pharyngeal clearance. The sensory nerve action potential (SNAP) amplitudes of median and ulnar nerves were decreased. Intravenous immunoglobulin therapy and plasma exchange ameliorated his dysesthesia and dysphagia after several weeks, and resulted in improvements in VF and SNAP abnormalities. These observations suggest that FOSMN syndrome maybe, in part, immune-mediated.
| Original language | English |
|---|---|
| Pages (from-to) | 157-158 |
| Number of pages | 2 |
| Journal | Journal of the Neurological Sciences |
| Volume | 275 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Dec 15 2008 |
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All Science Journal Classification (ASJC) codes
- Neurology
- Clinical Neurology
Cite this
Facial onset sensory and motor neuronopathy (FOSMN) syndrome responding to immunotherapies. / Hokonohara, Toshihiro; Shigeto, Hiroshi; Kawano, Yuji; Ohyagi, Yasumasa; Uehara, Michiya; Kira, Jun-Ichi.
In: Journal of the Neurological Sciences, Vol. 275, No. 1-2, 15.12.2008, p. 157-158.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Facial onset sensory and motor neuronopathy (FOSMN) syndrome responding to immunotherapies
AU - Hokonohara, Toshihiro
AU - Shigeto, Hiroshi
AU - Kawano, Yuji
AU - Ohyagi, Yasumasa
AU - Uehara, Michiya
AU - Kira, Jun-Ichi
PY - 2008/12/15
Y1 - 2008/12/15
N2 - We report the first non-Caucasian case of facial onset sensory and motor neuronopathy (FOSMN) syndrome partially responding to various immunotherapies. A 55-year-old man had first felt paresthesia on his right cheek at age 45. This gradually extended to the scalp. Paresthesia of bilateral fingers and dysphagia appeared 6 years later. On admission, facial sensory impairment and bulbar palsy were found. There were no sensory or motor deficits evident in any limb, except for decreased deep tendon reflex and vibratory sensation. Videofluorography (VF) revealed decreased pharyngeal clearance. The sensory nerve action potential (SNAP) amplitudes of median and ulnar nerves were decreased. Intravenous immunoglobulin therapy and plasma exchange ameliorated his dysesthesia and dysphagia after several weeks, and resulted in improvements in VF and SNAP abnormalities. These observations suggest that FOSMN syndrome maybe, in part, immune-mediated.
AB - We report the first non-Caucasian case of facial onset sensory and motor neuronopathy (FOSMN) syndrome partially responding to various immunotherapies. A 55-year-old man had first felt paresthesia on his right cheek at age 45. This gradually extended to the scalp. Paresthesia of bilateral fingers and dysphagia appeared 6 years later. On admission, facial sensory impairment and bulbar palsy were found. There were no sensory or motor deficits evident in any limb, except for decreased deep tendon reflex and vibratory sensation. Videofluorography (VF) revealed decreased pharyngeal clearance. The sensory nerve action potential (SNAP) amplitudes of median and ulnar nerves were decreased. Intravenous immunoglobulin therapy and plasma exchange ameliorated his dysesthesia and dysphagia after several weeks, and resulted in improvements in VF and SNAP abnormalities. These observations suggest that FOSMN syndrome maybe, in part, immune-mediated.
UR - http://www.scopus.com/inward/record.url?scp=55649116853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55649116853&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2008.07.021
DO - 10.1016/j.jns.2008.07.021
M3 - Article
C2 - 18722628
AN - SCOPUS:55649116853
VL - 275
SP - 157
EP - 158
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
SN - 0022-510X
IS - 1-2
ER -