Facial onset sensory and motor neuronopathy (FOSMN) syndrome responding to immunotherapies

Toshihiro Hokonohara, Hiroshi Shigeto, Yuji Kawano, Yasumasa Ohyagi, Michiya Uehara, Jun-Ichi Kira

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We report the first non-Caucasian case of facial onset sensory and motor neuronopathy (FOSMN) syndrome partially responding to various immunotherapies. A 55-year-old man had first felt paresthesia on his right cheek at age 45. This gradually extended to the scalp. Paresthesia of bilateral fingers and dysphagia appeared 6 years later. On admission, facial sensory impairment and bulbar palsy were found. There were no sensory or motor deficits evident in any limb, except for decreased deep tendon reflex and vibratory sensation. Videofluorography (VF) revealed decreased pharyngeal clearance. The sensory nerve action potential (SNAP) amplitudes of median and ulnar nerves were decreased. Intravenous immunoglobulin therapy and plasma exchange ameliorated his dysesthesia and dysphagia after several weeks, and resulted in improvements in VF and SNAP abnormalities. These observations suggest that FOSMN syndrome maybe, in part, immune-mediated.

Original languageEnglish
Pages (from-to)157-158
Number of pages2
JournalJournal of the Neurological Sciences
Volume275
Issue number1-2
DOIs
Publication statusPublished - Dec 15 2008

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Paresthesia
Immunotherapy
Deglutition Disorders
Action Potentials
Progressive Bulbar Palsy
Stretch Reflex
Ulnar Nerve
Plasma Exchange
Passive Immunization
Cheek
Median Nerve
Intravenous Immunoglobulins
Scalp
Fingers
Extremities

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Facial onset sensory and motor neuronopathy (FOSMN) syndrome responding to immunotherapies. / Hokonohara, Toshihiro; Shigeto, Hiroshi; Kawano, Yuji; Ohyagi, Yasumasa; Uehara, Michiya; Kira, Jun-Ichi.

In: Journal of the Neurological Sciences, Vol. 275, No. 1-2, 15.12.2008, p. 157-158.

Research output: Contribution to journalArticle

Hokonohara, Toshihiro ; Shigeto, Hiroshi ; Kawano, Yuji ; Ohyagi, Yasumasa ; Uehara, Michiya ; Kira, Jun-Ichi. / Facial onset sensory and motor neuronopathy (FOSMN) syndrome responding to immunotherapies. In: Journal of the Neurological Sciences. 2008 ; Vol. 275, No. 1-2. pp. 157-158.
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