Facile enantiomer analysis by combination of N-dansyl amino acid as diastereomerizer and molecular-shape recognitive RP-HPLC using comb-shaped polymer-immobilized silica

H. Ihara, M. Takafuji, T. Sakurai, H. Tsukamoto, A. Shundo, T. Sagawa, S. Nagaoka

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Poly(octadecyl acrylate)-grafted silica has been developed as a special stationary phase showing molecular-shape recognition in high-performance liquid chromatography. The bonded polymer phase is characterized by the fact that the polymer forms highly-ordered structures similar to a solvated crystalline state on silica and multiple π-π interaction between carbonyl groups in the polymer and aromatic solutes is promoted. This paper shows that the selectivity for DL-amino acids diastereomerized with N-dansyl L-proline can be enhanced by using the polymer stationary phase instead of octadecylated silica (ODS).

Original languageEnglish
Pages (from-to)2561-2572
Number of pages12
JournalJournal of Liquid Chromatography and Related Technologies
Volume27
Issue number16
DOIs
Publication statusPublished - Oct 11 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Pharmaceutical Science
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Facile enantiomer analysis by combination of N-dansyl amino acid as diastereomerizer and molecular-shape recognitive RP-HPLC using comb-shaped polymer-immobilized silica'. Together they form a unique fingerprint.

Cite this