Facile Preparation of Delivery Platform of Water-Soluble Low-Molecular-Weight Drugs Based on Polyion Complex Vesicle (PICsome) Encapsulating Mesoporous Silica Nanoparticle

Akinori Goto, Hung Chi Yen, Yasutaka Anraku, Shigeto Fukushima, Ping Shan Lai, Masaru Kato, Akihiro Kishimura, Kazunori Kataoka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Polyion complex vesicles (PICsomes) are polymeric hollow capsules composed of a unique semipermeable membrane, which may represent a versatile platform for constructing drug-loaded nanoformulation. However, it is difficult to retain water-soluble low-molecular-weight compounds (LMWCs) in the inner space of PICsome because of the high permeability of PIC membrane for LMWCs. Herein, we selected mesoporous silica nanoparticle (MSN) as a drug-retaining nanomatrix, and we demonstrated successful encapsulation of MSN into the PICsome to obtain MSN@PICsome. The efficacy of MSN loading, a ratio of the amount of MSN encapsulated in the PICsome to the amount of feed MSN, was at most 83%, and the diameter of resulting product was approximately 100 nm. The obtained MSN@PICsome was stably dispersed under the physiological condition, and showed considerable longevity in blood circulation of mice. Furthermore, the surface of MSN in MSN@PICsome can be modified without any deterioration of the vesicle structure, obtaining amino-functionalized and sulfonate-functionalized MSN@PICsomes (A-MSN@PICsome and S-MSN@PICsome, respectively). Both surface-modified MSN@PICsomes were successfully loaded with charged water-soluble low-molecular-weight compounds (LMWCs). Particularly, S-MSN@PICsome kept 8 wt % gemcitabine (GEM) per S-MSN, and released it in a sustained manner. GEM-loaded S-MSN@PICsome demonstrated marked cytotoxicity against cultured tumor cells, and achieved significant in vivo efficacy to suppress the growth of subcutaneously implanted lung tumor via intravenous administration.

Original languageEnglish
Pages (from-to)807-815
Number of pages9
JournalACS Biomaterials Science and Engineering
Volume3
Issue number5
DOIs
Publication statusPublished - May 8 2017

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Silicon Dioxide
Molecular weight
Silica
Nanoparticles
Water
Pharmaceutical Preparations
gemcitabine
Tumors
Membranes
Hemodynamics
Cytotoxicity
Encapsulation
Capsules
Deterioration

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Facile Preparation of Delivery Platform of Water-Soluble Low-Molecular-Weight Drugs Based on Polyion Complex Vesicle (PICsome) Encapsulating Mesoporous Silica Nanoparticle. / Goto, Akinori; Yen, Hung Chi; Anraku, Yasutaka; Fukushima, Shigeto; Lai, Ping Shan; Kato, Masaru; Kishimura, Akihiro; Kataoka, Kazunori.

In: ACS Biomaterials Science and Engineering, Vol. 3, No. 5, 08.05.2017, p. 807-815.

Research output: Contribution to journalArticle

Goto, Akinori ; Yen, Hung Chi ; Anraku, Yasutaka ; Fukushima, Shigeto ; Lai, Ping Shan ; Kato, Masaru ; Kishimura, Akihiro ; Kataoka, Kazunori. / Facile Preparation of Delivery Platform of Water-Soluble Low-Molecular-Weight Drugs Based on Polyion Complex Vesicle (PICsome) Encapsulating Mesoporous Silica Nanoparticle. In: ACS Biomaterials Science and Engineering. 2017 ; Vol. 3, No. 5. pp. 807-815.
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AU - Yen, Hung Chi

AU - Anraku, Yasutaka

AU - Fukushima, Shigeto

AU - Lai, Ping Shan

AU - Kato, Masaru

AU - Kishimura, Akihiro

AU - Kataoka, Kazunori

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