TY - JOUR
T1 - Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
AU - Nagamachi, Miyako
AU - Sakata, Daiji
AU - Kabashima, Kenji
AU - Furuyashiki, Tomoyuki
AU - Murata, Takahiko
AU - Segi-Nishida, Eri
AU - Soontrapa, Kitipong
AU - Matsuoka, Toshiyuki
AU - Miyachi, Yoshiki
AU - Narumiya, Shuh
PY - 2007/11/26
Y1 - 2007/11/26
N2 - Prostaglandin E2 (PGE2) exerts its actions via four subtypes of the PGE receptor, EP1-4. We show that mice deficient in EP1 exhibited significantly attenuated Th1 response in contact hypersensitivity induced by dinitrofluorobenzene (DNFB). This phenotype was recapitulated in wild-type mice by administration of an EP1-selective antagonist during the sensitization phase, and by adoptive transfer of T cells from sensitized EP1-/- mice. Conversely, an EP1-selective agonist facilitated Th1 differentiation of naive T cells in vitro. Finally, CD11c+ cells containing the inducible form of PGE synthase increased in number in the draining lymph nodes after DNFB application. These results suggest that PGE 2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation. JEM
AB - Prostaglandin E2 (PGE2) exerts its actions via four subtypes of the PGE receptor, EP1-4. We show that mice deficient in EP1 exhibited significantly attenuated Th1 response in contact hypersensitivity induced by dinitrofluorobenzene (DNFB). This phenotype was recapitulated in wild-type mice by administration of an EP1-selective antagonist during the sensitization phase, and by adoptive transfer of T cells from sensitized EP1-/- mice. Conversely, an EP1-selective agonist facilitated Th1 differentiation of naive T cells in vitro. Finally, CD11c+ cells containing the inducible form of PGE synthase increased in number in the draining lymph nodes after DNFB application. These results suggest that PGE 2 produced by dendritic cells in the lymph nodes acts on EP1 in naive T cells to promote Th1 differentiation. JEM
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U2 - 10.1084/jem.20070773
DO - 10.1084/jem.20070773
M3 - Article
C2 - 17967902
AN - SCOPUS:36549079007
SN - 0022-1007
VL - 204
SP - 2865
EP - 2874
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 12
ER -