TY - JOUR
T1 - Factor B is the second lipopolysaccharide-binding protease zymogen in the horseshoe crab coagulation cascade
AU - Kobayashi, Yuki
AU - Takahashi, Toshiaki
AU - Shibata, Toshio
AU - Ikeda, Shunsuke
AU - Koshiba, Takumi
AU - Mizumura, Hikaru
AU - Oda, Toshio
AU - Kawabata, Shun Ichiro
N1 - Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
PY - 2015/7/31
Y1 - 2015/7/31
N2 - Background: It is not known whether LPS is required for the activation of coagulation factor B. Results: Factor B is an LPS-binding zymogen activated by -factor C in an LPS-dependent manner. Conclusion: The clip domain of factor B has an important role in localizing factor B to LPS. Significance: Horseshoe crab coagulation is an ideal model for understanding proteolytic cascades.
AB - Background: It is not known whether LPS is required for the activation of coagulation factor B. Results: Factor B is an LPS-binding zymogen activated by -factor C in an LPS-dependent manner. Conclusion: The clip domain of factor B has an important role in localizing factor B to LPS. Significance: Horseshoe crab coagulation is an ideal model for understanding proteolytic cascades.
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U2 - 10.1074/jbc.M115.653196
DO - 10.1074/jbc.M115.653196
M3 - Article
C2 - 26109069
AN - SCOPUS:84940483344
SN - 0021-9258
VL - 290
SP - 19379
EP - 19386
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 31
ER -