Factor B is the second lipopolysaccharide-binding protease zymogen in the horseshoe crab coagulation cascade

Yuki Kobayashi, Toshiaki Takahashi, Toshio Shibata, Shunsuke Ikeda, Takumi Koshiba, Hikaru Mizumura, Toshio Oda, Shun Ichiro Kawabata

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Background: It is not known whether LPS is required for the activation of coagulation factor B. Results: Factor B is an LPS-binding zymogen activated by -factor C in an LPS-dependent manner. Conclusion: The clip domain of factor B has an important role in localizing factor B to LPS. Significance: Horseshoe crab coagulation is an ideal model for understanding proteolytic cascades.

Original languageEnglish
Pages (from-to)19379-19386
Number of pages8
JournalJournal of Biological Chemistry
Issue number31
Publication statusPublished - Jul 31 2015


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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