Factors affecting the long-term postoperative prognosis of reflux nephropathy: 18Th Kyushu cooperative urological research

Hirofumi Matsuoka, Kazuna Tsubouchi, Masatoshi Tanaka, Nobuhiro Haga, Takanori Yamaguchi, Yasuhiro Koikawa, Minoru Miyazato, Seiichi Saito, Toshiharu Kihara, Yasuyoshi Miyata, Yasushi Mochizuki, Hideki Sakai, Hideki Enokida, Hiroshi Hayami, Masayuki Nakagawa, Ken Ichi Mori, Toshitaka Shin, Toshio Kamimura, Syoichiro Mukai, Toshiyuki KamotoJunichi Inokuchi, Masatoshi Eto, Naohiro Fujimoto, Shigetaka Suekane, Mitsunori Matsuo, Tsukasa Igawa, Shohei Tobu, Mitsuru Noguchi, Kazuhiko Nishi, Tomomi Kamba, Tatsu Ishii

Research output: Contribution to journalArticlepeer-review

Abstract

[Objective] To investigate the postoperative long-term prognosis and the factors predicting the renal function of patients with reflux nephropathy. (Materials and methods) This study examined s-Cr, urinary protein and blood pressure of patients who had undergone anti-reflux surgery 10 years earlier. It also calculated the postoperative estimated glomerular filtration rate (eGFR) and examined the correlation between the eGFR and preoperative factors, while also analyzing factors associated with long-term prognosis. [Results) The study population was 51 infants (37 boys and 14 girls). The mean age of the patients at surgery was 3.41 ± 3.61 years. The postoperative eGFR was a mean of 90.27 ± 20.42 ml/min/1.73 m2and was primarily correlated with age, primary diagnosis, reflux grade, degree of renal parenchymal damage, s-Cr abnormality, and proteinuria at baseline. A total of 20 patients had chronic kidney disease. Multiple regression analysis of these factors revealed that an older age (P=0.0021), a reflux grade of ≥ 8 (P=0.0134), and the degree of renal parenchymal damage (group≥2b, P<0.0001) were significantly associated with the long-term postoperative prognosis of reflux nephropathy. Using these three factors, this study derived a multiple regression equation for estimating eGFR in the 10th year after surgery. [Conclusions] Age, reflux grade, and degree of renal parenchymal damage at baseline were factors that affected long-term postoperative prognosis of reflux nephropathy. Patients with high-grade reflux (reflux grade≥8) and severe renal parenchymal damage (group≥2b) were more likely to show a reduced CKD level at 10 years after anti-reflux surgery.

Original languageEnglish
Pages (from-to)570-578
Number of pages9
JournalNishinihon Journal of Urology
Volume82
Issue number86
Publication statusPublished - Feb 2021

All Science Journal Classification (ASJC) codes

  • Urology

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