Factors Associated with Antidepressant Dosing in Asia: Findings from the Research on Asian Psychotropic Prescription Study

Kamini Rajaratnam, Yu Tao Xiang, Adarsh Tripathi, Helen Fung Kum Chiu, Tian Mei Si, Kok Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan Ling He, Min Soo Lee, Shu Yu Yang, Pichet Udomratn, Roy Abraham Kallivayalil, Andi J. Tanra, Margarita Maramis, Winston Wu Dien Shen, Norman SartoriusEe Heok Kua, Chay Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J. Baldessarini, Kang Sim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods. The AD doses varied by twofold among countries (highest in PR China and RO Korea, lowest in Singapore and Indonesia), and averaged 124 (120-129) mg/d imipramine-equivalents. Average daily doses increased by 12% between 2004 and 2013. Doses were significantly higher among hospitalized patients and ranked by diagnosis: major depression > anxiety disorders > bipolar disorder, but were not associated with private/public or psychiatric/general-medical settings, nor with age, sex, or cotreatment with a mood stabilizer. In multivariate modeling, AD-dose remained significantly associated with major depressive disorder and being hospitalized. Doses of ADs have increased somewhat in Asia and were higher when used for major depression or anxiety disorders than for bipolar depression and for hospitalized psychiatric patients.

Original languageEnglish
Pages (from-to)716-719
Number of pages4
JournalJournal of Clinical Psychopharmacology
Volume36
Issue number6
DOIs
Publication statusPublished - Dec 1 2016

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Antidepressive Agents
Prescriptions
Research
Anxiety Disorders
Bipolar Disorder
Psychiatry
Depression
Indonesia
Imipramine
Singapore
Major Depressive Disorder
Korea
China
Cross-Sectional Studies
Demography

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Factors Associated with Antidepressant Dosing in Asia : Findings from the Research on Asian Psychotropic Prescription Study. / Rajaratnam, Kamini; Xiang, Yu Tao; Tripathi, Adarsh; Chiu, Helen Fung Kum; Si, Tian Mei; Chee, Kok Yoon; Avasthi, Ajit; Grover, Sandeep; Chong, Mian Yoon; Kuga, Hironori; Kanba, Shigenobu; He, Yan Ling; Lee, Min Soo; Yang, Shu Yu; Udomratn, Pichet; Kallivayalil, Roy Abraham; Tanra, Andi J.; Maramis, Margarita; Shen, Winston Wu Dien; Sartorius, Norman; Kua, Ee Heok; Tan, Chay Hoon; Mahendran, Rathi; Shinfuku, Naotaka; Sum, Min Yi; Baldessarini, Ross J.; Sim, Kang.

In: Journal of Clinical Psychopharmacology, Vol. 36, No. 6, 01.12.2016, p. 716-719.

Research output: Contribution to journalArticle

Rajaratnam, K, Xiang, YT, Tripathi, A, Chiu, HFK, Si, TM, Chee, KY, Avasthi, A, Grover, S, Chong, MY, Kuga, H, Kanba, S, He, YL, Lee, MS, Yang, SY, Udomratn, P, Kallivayalil, RA, Tanra, AJ, Maramis, M, Shen, WWD, Sartorius, N, Kua, EH, Tan, CH, Mahendran, R, Shinfuku, N, Sum, MY, Baldessarini, RJ & Sim, K 2016, 'Factors Associated with Antidepressant Dosing in Asia: Findings from the Research on Asian Psychotropic Prescription Study', Journal of Clinical Psychopharmacology, vol. 36, no. 6, pp. 716-719. https://doi.org/10.1097/JCP.0000000000000591
Rajaratnam, Kamini ; Xiang, Yu Tao ; Tripathi, Adarsh ; Chiu, Helen Fung Kum ; Si, Tian Mei ; Chee, Kok Yoon ; Avasthi, Ajit ; Grover, Sandeep ; Chong, Mian Yoon ; Kuga, Hironori ; Kanba, Shigenobu ; He, Yan Ling ; Lee, Min Soo ; Yang, Shu Yu ; Udomratn, Pichet ; Kallivayalil, Roy Abraham ; Tanra, Andi J. ; Maramis, Margarita ; Shen, Winston Wu Dien ; Sartorius, Norman ; Kua, Ee Heok ; Tan, Chay Hoon ; Mahendran, Rathi ; Shinfuku, Naotaka ; Sum, Min Yi ; Baldessarini, Ross J. ; Sim, Kang. / Factors Associated with Antidepressant Dosing in Asia : Findings from the Research on Asian Psychotropic Prescription Study. In: Journal of Clinical Psychopharmacology. 2016 ; Vol. 36, No. 6. pp. 716-719.
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AU - Rajaratnam, Kamini

AU - Xiang, Yu Tao

AU - Tripathi, Adarsh

AU - Chiu, Helen Fung Kum

AU - Si, Tian Mei

AU - Chee, Kok Yoon

AU - Avasthi, Ajit

AU - Grover, Sandeep

AU - Chong, Mian Yoon

AU - Kuga, Hironori

AU - Kanba, Shigenobu

AU - He, Yan Ling

AU - Lee, Min Soo

AU - Yang, Shu Yu

AU - Udomratn, Pichet

AU - Kallivayalil, Roy Abraham

AU - Tanra, Andi J.

AU - Maramis, Margarita

AU - Shen, Winston Wu Dien

AU - Sartorius, Norman

AU - Kua, Ee Heok

AU - Tan, Chay Hoon

AU - Mahendran, Rathi

AU - Shinfuku, Naotaka

AU - Sum, Min Yi

AU - Baldessarini, Ross J.

AU - Sim, Kang

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N2 - In this study, we sought to examine factors associated with dosing of antidepressants (ADs) in Asia. Based on reported data and clinical experience, we hypothesized that doses of ADs would be associated with demographic and clinical factors and would increase over time. This cross-sectional, pharmacoepidemiological study analyzed data collected within the Research Study on Asian Psychotropic Prescription Pattern for Antidepressants from 4164 participants in 10 Asian countries, using univariate and multivariate methods. The AD doses varied by twofold among countries (highest in PR China and RO Korea, lowest in Singapore and Indonesia), and averaged 124 (120-129) mg/d imipramine-equivalents. Average daily doses increased by 12% between 2004 and 2013. Doses were significantly higher among hospitalized patients and ranked by diagnosis: major depression > anxiety disorders > bipolar disorder, but were not associated with private/public or psychiatric/general-medical settings, nor with age, sex, or cotreatment with a mood stabilizer. In multivariate modeling, AD-dose remained significantly associated with major depressive disorder and being hospitalized. Doses of ADs have increased somewhat in Asia and were higher when used for major depression or anxiety disorders than for bipolar depression and for hospitalized psychiatric patients.

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