False-positive findings for tumor markers after curative gastrectomy for gastric cancer

Takao Ohtsuka, Seiji Sato, Yoshihiko Kitajima, Masayuki Tanaka, Yuji Nakafusa, Kohji Miyazaki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The objective of this study was to assess the frequency and characteristics of false-positive results for tumor markers after curative gastrectomy for gastric cancer. Carcinoembryonic antigen and/or carbohydrate antigen 19-9 were periodically assessed for 168 patients who underwent curative gastrectomy. Cancer recurrence was observed for 17 (10.1%) patients and 151 (89.9%) were disease-free during the mean follow-up period of 23.1 months after the operation. The frequency of false-positive findings for tumor markers after gastrectomy was 14.3% (24/168) for all followed-up patients. Three different patterns of marker elevation were observed in the false-positive group. A false-positive finding for these markers was observed for patients with early-stage cancer and for those with chronic benign diseases, for example bronchitis, liver dysfunction, diabetes mellitus, and renal dysfunction. For most patients with false-positive findings for a marker a spontaneous decrease in the tumor marker was observed 1-2 months after the marker was first observed at a high level after the operation. Surgeons and oncologists should therefore keep in mind the high frequency of false-positive findings for tumor markers after curative gastrectomy for gastric cancer.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalDigestive Diseases and Sciences
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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Gastrectomy
Tumor Biomarkers
Stomach Neoplasms
Bronchitis
Carcinoembryonic Antigen
Liver Diseases
Neoplasms
Diabetes Mellitus
Chronic Disease
Carbohydrates
Kidney
Antigens
Recurrence

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

False-positive findings for tumor markers after curative gastrectomy for gastric cancer. / Ohtsuka, Takao; Sato, Seiji; Kitajima, Yoshihiko; Tanaka, Masayuki; Nakafusa, Yuji; Miyazaki, Kohji.

In: Digestive Diseases and Sciences, Vol. 53, No. 1, 01.01.2008, p. 73-79.

Research output: Contribution to journalArticle

Ohtsuka, Takao ; Sato, Seiji ; Kitajima, Yoshihiko ; Tanaka, Masayuki ; Nakafusa, Yuji ; Miyazaki, Kohji. / False-positive findings for tumor markers after curative gastrectomy for gastric cancer. In: Digestive Diseases and Sciences. 2008 ; Vol. 53, No. 1. pp. 73-79.
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