Family analysis of Werner's syndrome

A survey of 42 Japanese families with a review of the literature

M. Goto, K. Tanimoto, Y. Horiuchi, Takehiko Sasazuki

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Forty-two Japanese families, including 80 individuals with Werner's syndrome were studied, confirming that this syndrome is inherited as an autosomal recessive trait. The incidence of malignancy was relatively high in these families and individuals with Werner's syndrome, although the incidence was not so high as was reported previously. HLA typing revealed no significant linkage with Werner's syndrome. The frequency of Werner's syndrome in Japan was estimated using two methods which indicated approximately 300 cases among 100 million people.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalClinical Genetics
Volume19
Issue number1
Publication statusPublished - 1981
Externally publishedYes

Fingerprint

Werner Syndrome
Histocompatibility Testing
Incidence
Japan
Surveys and Questionnaires
Neoplasms

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Family analysis of Werner's syndrome : A survey of 42 Japanese families with a review of the literature. / Goto, M.; Tanimoto, K.; Horiuchi, Y.; Sasazuki, Takehiko.

In: Clinical Genetics, Vol. 19, No. 1, 1981, p. 8-15.

Research output: Contribution to journalArticle

Goto, M, Tanimoto, K, Horiuchi, Y & Sasazuki, T 1981, 'Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature', Clinical Genetics, vol. 19, no. 1, pp. 8-15.
Goto, M. ; Tanimoto, K. ; Horiuchi, Y. ; Sasazuki, Takehiko. / Family analysis of Werner's syndrome : A survey of 42 Japanese families with a review of the literature. In: Clinical Genetics. 1981 ; Vol. 19, No. 1. pp. 8-15.
@article{9c816e0002694514b9ecc868e76b13d4,
title = "Family analysis of Werner's syndrome: A survey of 42 Japanese families with a review of the literature",
abstract = "Forty-two Japanese families, including 80 individuals with Werner's syndrome were studied, confirming that this syndrome is inherited as an autosomal recessive trait. The incidence of malignancy was relatively high in these families and individuals with Werner's syndrome, although the incidence was not so high as was reported previously. HLA typing revealed no significant linkage with Werner's syndrome. The frequency of Werner's syndrome in Japan was estimated using two methods which indicated approximately 300 cases among 100 million people.",
author = "M. Goto and K. Tanimoto and Y. Horiuchi and Takehiko Sasazuki",
year = "1981",
language = "English",
volume = "19",
pages = "8--15",
journal = "Clinical Genetics",
issn = "0009-9163",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Family analysis of Werner's syndrome

T2 - A survey of 42 Japanese families with a review of the literature

AU - Goto, M.

AU - Tanimoto, K.

AU - Horiuchi, Y.

AU - Sasazuki, Takehiko

PY - 1981

Y1 - 1981

N2 - Forty-two Japanese families, including 80 individuals with Werner's syndrome were studied, confirming that this syndrome is inherited as an autosomal recessive trait. The incidence of malignancy was relatively high in these families and individuals with Werner's syndrome, although the incidence was not so high as was reported previously. HLA typing revealed no significant linkage with Werner's syndrome. The frequency of Werner's syndrome in Japan was estimated using two methods which indicated approximately 300 cases among 100 million people.

AB - Forty-two Japanese families, including 80 individuals with Werner's syndrome were studied, confirming that this syndrome is inherited as an autosomal recessive trait. The incidence of malignancy was relatively high in these families and individuals with Werner's syndrome, although the incidence was not so high as was reported previously. HLA typing revealed no significant linkage with Werner's syndrome. The frequency of Werner's syndrome in Japan was estimated using two methods which indicated approximately 300 cases among 100 million people.

UR - http://www.scopus.com/inward/record.url?scp=0019507754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019507754&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 8

EP - 15

JO - Clinical Genetics

JF - Clinical Genetics

SN - 0009-9163

IS - 1

ER -