Fascin expression in progression and prognosis of hepatocellular carcinoma

Tomohiro Iguchi, Shinichi Aishima, Kenji Umeda, Kensaku Sanefuji, Nobuhiro Fujita, Keishi Sugimachi, Tomonobu Gion, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background and Objectives: Fascin is an actin-bundling protein and induces membrane protrusions and cell motility after the formation of lamellipodia or filopodia. Fascin expression has been reported to be associated with progression or prognosis in various neoplasms, but the role of fascin in hepatocellular carcinoma (HCC) remains unknown. The aim of this study was to investigate the clinicopathological and prognostic relevance of fascin by immunohistochemistry. Methods: A total of 137 patients with HCC were stained with anti-fascin antibody. The tumor cells having unequivocal cytoplasmic and/or membranous fascin immunoreactivity were defined as fascin-positive. Results: Immunohistochemically, 23 (16.8%) HCCs having unequivocal fascin immunoreactivity were found. Tumors showing fascin expression were larger and less differentiated than those showing no fascin expression (P = 0.0239 and 0.0018, respectively). Portal venous invasion, bile duct invasion, and intrahepatic metastasis were detected significantly more frequently in fascin-positive group (P = 0.0029, 0.0333, and 0.0403, respectively). In addition, high alpha-fetoprotein (AFP) levels were significantly associated with the fascin expression in HCC (P = 0.0116). Fascin-positive group had significantly poorer outcomes than fascin-negative group and was an independent prognostic factor for disease-free survival. Conclusions: Fascin might become a novel marker of progression in HCC and a significant indicator of a poor prognosis for patients with HCC.

Original languageEnglish
Pages (from-to)575-579
Number of pages5
JournalJournal of Surgical Oncology
Volume100
Issue number7
DOIs
Publication statusPublished - Dec 1 2009

Fingerprint

Hepatocellular Carcinoma
Pseudopodia
fascin
Intrahepatic Bile Ducts
Neoplasms
alpha-Fetoproteins
Disease-Free Survival
Cell Movement
Actins
Anti-Idiotypic Antibodies
Membrane Proteins
Immunohistochemistry
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Iguchi, T., Aishima, S., Umeda, K., Sanefuji, K., Fujita, N., Sugimachi, K., ... Tsuneyoshi, M. (2009). Fascin expression in progression and prognosis of hepatocellular carcinoma. Journal of Surgical Oncology, 100(7), 575-579. https://doi.org/10.1002/jso.21377

Fascin expression in progression and prognosis of hepatocellular carcinoma. / Iguchi, Tomohiro; Aishima, Shinichi; Umeda, Kenji; Sanefuji, Kensaku; Fujita, Nobuhiro; Sugimachi, Keishi; Gion, Tomonobu; Taketomi, Akinobu; Maehara, Yoshihiko; Tsuneyoshi, Masazumi.

In: Journal of Surgical Oncology, Vol. 100, No. 7, 01.12.2009, p. 575-579.

Research output: Contribution to journalArticle

Iguchi, T, Aishima, S, Umeda, K, Sanefuji, K, Fujita, N, Sugimachi, K, Gion, T, Taketomi, A, Maehara, Y & Tsuneyoshi, M 2009, 'Fascin expression in progression and prognosis of hepatocellular carcinoma', Journal of Surgical Oncology, vol. 100, no. 7, pp. 575-579. https://doi.org/10.1002/jso.21377
Iguchi T, Aishima S, Umeda K, Sanefuji K, Fujita N, Sugimachi K et al. Fascin expression in progression and prognosis of hepatocellular carcinoma. Journal of Surgical Oncology. 2009 Dec 1;100(7):575-579. https://doi.org/10.1002/jso.21377
Iguchi, Tomohiro ; Aishima, Shinichi ; Umeda, Kenji ; Sanefuji, Kensaku ; Fujita, Nobuhiro ; Sugimachi, Keishi ; Gion, Tomonobu ; Taketomi, Akinobu ; Maehara, Yoshihiko ; Tsuneyoshi, Masazumi. / Fascin expression in progression and prognosis of hepatocellular carcinoma. In: Journal of Surgical Oncology. 2009 ; Vol. 100, No. 7. pp. 575-579.
@article{297300bbbc094ebdb8fe85edcb66b025,
title = "Fascin expression in progression and prognosis of hepatocellular carcinoma",
abstract = "Background and Objectives: Fascin is an actin-bundling protein and induces membrane protrusions and cell motility after the formation of lamellipodia or filopodia. Fascin expression has been reported to be associated with progression or prognosis in various neoplasms, but the role of fascin in hepatocellular carcinoma (HCC) remains unknown. The aim of this study was to investigate the clinicopathological and prognostic relevance of fascin by immunohistochemistry. Methods: A total of 137 patients with HCC were stained with anti-fascin antibody. The tumor cells having unequivocal cytoplasmic and/or membranous fascin immunoreactivity were defined as fascin-positive. Results: Immunohistochemically, 23 (16.8{\%}) HCCs having unequivocal fascin immunoreactivity were found. Tumors showing fascin expression were larger and less differentiated than those showing no fascin expression (P = 0.0239 and 0.0018, respectively). Portal venous invasion, bile duct invasion, and intrahepatic metastasis were detected significantly more frequently in fascin-positive group (P = 0.0029, 0.0333, and 0.0403, respectively). In addition, high alpha-fetoprotein (AFP) levels were significantly associated with the fascin expression in HCC (P = 0.0116). Fascin-positive group had significantly poorer outcomes than fascin-negative group and was an independent prognostic factor for disease-free survival. Conclusions: Fascin might become a novel marker of progression in HCC and a significant indicator of a poor prognosis for patients with HCC.",
author = "Tomohiro Iguchi and Shinichi Aishima and Kenji Umeda and Kensaku Sanefuji and Nobuhiro Fujita and Keishi Sugimachi and Tomonobu Gion and Akinobu Taketomi and Yoshihiko Maehara and Masazumi Tsuneyoshi",
year = "2009",
month = "12",
day = "1",
doi = "10.1002/jso.21377",
language = "English",
volume = "100",
pages = "575--579",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Fascin expression in progression and prognosis of hepatocellular carcinoma

AU - Iguchi, Tomohiro

AU - Aishima, Shinichi

AU - Umeda, Kenji

AU - Sanefuji, Kensaku

AU - Fujita, Nobuhiro

AU - Sugimachi, Keishi

AU - Gion, Tomonobu

AU - Taketomi, Akinobu

AU - Maehara, Yoshihiko

AU - Tsuneyoshi, Masazumi

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Background and Objectives: Fascin is an actin-bundling protein and induces membrane protrusions and cell motility after the formation of lamellipodia or filopodia. Fascin expression has been reported to be associated with progression or prognosis in various neoplasms, but the role of fascin in hepatocellular carcinoma (HCC) remains unknown. The aim of this study was to investigate the clinicopathological and prognostic relevance of fascin by immunohistochemistry. Methods: A total of 137 patients with HCC were stained with anti-fascin antibody. The tumor cells having unequivocal cytoplasmic and/or membranous fascin immunoreactivity were defined as fascin-positive. Results: Immunohistochemically, 23 (16.8%) HCCs having unequivocal fascin immunoreactivity were found. Tumors showing fascin expression were larger and less differentiated than those showing no fascin expression (P = 0.0239 and 0.0018, respectively). Portal venous invasion, bile duct invasion, and intrahepatic metastasis were detected significantly more frequently in fascin-positive group (P = 0.0029, 0.0333, and 0.0403, respectively). In addition, high alpha-fetoprotein (AFP) levels were significantly associated with the fascin expression in HCC (P = 0.0116). Fascin-positive group had significantly poorer outcomes than fascin-negative group and was an independent prognostic factor for disease-free survival. Conclusions: Fascin might become a novel marker of progression in HCC and a significant indicator of a poor prognosis for patients with HCC.

AB - Background and Objectives: Fascin is an actin-bundling protein and induces membrane protrusions and cell motility after the formation of lamellipodia or filopodia. Fascin expression has been reported to be associated with progression or prognosis in various neoplasms, but the role of fascin in hepatocellular carcinoma (HCC) remains unknown. The aim of this study was to investigate the clinicopathological and prognostic relevance of fascin by immunohistochemistry. Methods: A total of 137 patients with HCC were stained with anti-fascin antibody. The tumor cells having unequivocal cytoplasmic and/or membranous fascin immunoreactivity were defined as fascin-positive. Results: Immunohistochemically, 23 (16.8%) HCCs having unequivocal fascin immunoreactivity were found. Tumors showing fascin expression were larger and less differentiated than those showing no fascin expression (P = 0.0239 and 0.0018, respectively). Portal venous invasion, bile duct invasion, and intrahepatic metastasis were detected significantly more frequently in fascin-positive group (P = 0.0029, 0.0333, and 0.0403, respectively). In addition, high alpha-fetoprotein (AFP) levels were significantly associated with the fascin expression in HCC (P = 0.0116). Fascin-positive group had significantly poorer outcomes than fascin-negative group and was an independent prognostic factor for disease-free survival. Conclusions: Fascin might become a novel marker of progression in HCC and a significant indicator of a poor prognosis for patients with HCC.

UR - http://www.scopus.com/inward/record.url?scp=71549135533&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71549135533&partnerID=8YFLogxK

U2 - 10.1002/jso.21377

DO - 10.1002/jso.21377

M3 - Article

C2 - 19697358

AN - SCOPUS:71549135533

VL - 100

SP - 575

EP - 579

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 7

ER -