Fast-twitch muscle hypertrophy partly induces lipid accumulation inhibition with Alaska Pollack protein intake in rats

Takafumi Mizushige, Fuminori Kawabata, Keisuke Uozumi, Tomoko Tsuji, Taro Kishida, Kiyoshi Ebihara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Fish protein is a source of animal protein that is consumed worldwide. Although it has been reported that the intake of Alaska pollack protein (APP) reduces serum triglyceride and body fat accumulation in rats, the mechanisms underlying these effects are poorly understood. In the present study, we fed 5-week-old male Sprague-Dawley rats a high-fat diet with APP or casein for 4 weeks. We reconformed that the intake of APP decreases serum triglycerides and inhibits visceral body fat accumulation in rats. We found that APP had a higher non-digestive protein content than casein, and the amount of protein in feces was higher in the APP group than in the casein group. However, the amount of total lipids in feces did not differ signifcantly between the groups. We also found that the gastrocnemius muscle, a fast-twitch muscle, tended to increase in weight, and that the epididymal fat weight correlated negatively with gastrocnemius muscle weight in the APP group. These results imply that the enhancement of basal energy expenditure by fast-twitch muscle hypertrophy, rather than the enhancement of lipid excretion via feces, partly causes APP-induced inhibition of lipid accumulation in rats.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalBiomedical Research
Volume31
Issue number6
DOIs
Publication statusPublished - Dec 1 2010

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Hypertrophy
Muscle
Rats
Lipids
Muscles
Proteins
Caseins
Feces
Fats
Weights and Measures
Adipose Tissue
Blood Proteins
Skeletal Muscle
Triglycerides
Fish Proteins
Intra-Abdominal Fat
High Fat Diet
Energy Metabolism
Nutrition
Sprague Dawley Rats

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Fast-twitch muscle hypertrophy partly induces lipid accumulation inhibition with Alaska Pollack protein intake in rats. / Mizushige, Takafumi; Kawabata, Fuminori; Uozumi, Keisuke; Tsuji, Tomoko; Kishida, Taro; Ebihara, Kiyoshi.

In: Biomedical Research, Vol. 31, No. 6, 01.12.2010, p. 347-352.

Research output: Contribution to journalArticle

Mizushige, Takafumi ; Kawabata, Fuminori ; Uozumi, Keisuke ; Tsuji, Tomoko ; Kishida, Taro ; Ebihara, Kiyoshi. / Fast-twitch muscle hypertrophy partly induces lipid accumulation inhibition with Alaska Pollack protein intake in rats. In: Biomedical Research. 2010 ; Vol. 31, No. 6. pp. 347-352.
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