Fasting triglyceride is a significant risk factor for coronary artery disease in middle-aged Japanese men - Results from a 10-year cohort study

Hiroki Satoh, Tetsuo Nishino, Kazuo Tomita, Hiroyuki Tsutsui

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: It has been well established that dyslipidemia is a significant risk factor for coronary artery disease (CAD), however, the association between fasting triglyceride (TG) and the occurrence of CAD is controversial. The objective of this study was to elucidate the relationship between fasting TG and CAD in middle-aged Japanese men. Methods and Results: A cohort study of 6,966 middle-aged Japanese men (mean±SD: 46.6±5.2 years) with a 10-year follow-up period was conducted to identify risk factors for the occurrence of CAD. One hundred and eleven cases of CAD were identified during the follow up. The Cox proportional hazard model was used to identify the independent risk factors for CAD. Adjustment was made for variables including age, body mass index, smoking habit, alcohol intake, duration of sleeping, systolic blood pressure, uric acid, total cholesterol, high-density lipoprotein cholesterol, fasting plasma glucose, and TG. Fasting TG was identified as an independent risk factor for CAD. The adjusted hazard ratio of TG for CAD was 3.07 (95% confidence interval: 1.01-9.35, p<0.05). Additionally, a serum TG concentration level greater than 78 mg/dl was a significant risk for CAD. Conclusions: By using the long term follow-up data of the study of middle-aged Japanese men, fasting TG was identified to be a significant risk factor for CAD.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalCirculation Journal
Volume70
Issue number3
DOIs
Publication statusPublished - Mar 7 2006

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Coronary Artery Disease
Fasting
Triglycerides
Cohort Studies
Blood Pressure
Social Adjustment
Dyslipidemias
Uric Acid
Proportional Hazards Models
HDL Cholesterol
Habits
Body Mass Index
Smoking
Cholesterol
Alcohols
Confidence Intervals
Glucose
Serum

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Fasting triglyceride is a significant risk factor for coronary artery disease in middle-aged Japanese men - Results from a 10-year cohort study. / Satoh, Hiroki; Nishino, Tetsuo; Tomita, Kazuo; Tsutsui, Hiroyuki.

In: Circulation Journal, Vol. 70, No. 3, 07.03.2006, p. 227-231.

Research output: Contribution to journalArticle

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