Fatal severe vasospasm due to rewarming following hypothermia

Hiroyuki Jimbo, Kenji Dohi, Yoshinori Nakamura, Hitoshi Izumiyama, Yukio Ikeda, Kiyoshi Matsumoto, Miki Kushima, Atsushi Takaki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 37-year-old female died of cerebral vasospasm as a complication of rewarming following hypothermia therapy for severe head injury. She presented with severe consciousness disturbance and anisocoria after falling down a flight of stairs. Computed tomography (CT) revealed a right acute subdural hematoma and temporal contusion. Following surgery, mild hypothermia was started and rewarming was completed by the 11th day. Neurological examination showed no abnormalities, but intracranial pressure (ICP) suddenly increased and she manifested anisocoria on the 13th day. Repeat CT revealed a low density area in the right middle cerebral artery region and cerebral angiography showed diffuse narrowing of the main arterial trunks. A cerebrospinal fluid (CSF) sample was collected using an intraventricular ICP monitoring catheter. The CSF level of 8-hydroxy-2'-deoxyguanosine was elevated during the rewarming period, indicating substantial deoxyribonucleic acid (DNA) oxidation. She died on the 15th day due to uncontrollable ICP. Histological examination at autopsy of the narrowed artery found the waving phenomenon in the internal elastic lamina and invasion of inflammatory cells into the adventitia. These findings constitute the possible evidence that free-radical-mediated oxidative DNA damage may be important in the genesis of severe vasospasm due to rewarming following hypothermia.

Original languageEnglish
Pages (from-to)463-466
Number of pages4
JournalNeurologia medico-chirurgica
Volume40
Issue number9
DOIs
Publication statusPublished - Jan 1 2000

Fingerprint

Rewarming
Hypothermia
Intracranial Pressure
Anisocoria
Cerebrospinal Fluid
Tomography
Hematoma, Subdural, Acute
Intracranial Vasospasm
Adventitia
Cerebral Angiography
Contusions
DNA
Middle Cerebral Artery
Neurologic Examination
Ventricular Pressure
Consciousness
Craniocerebral Trauma
Free Radicals
Autopsy
Catheters

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Jimbo, H., Dohi, K., Nakamura, Y., Izumiyama, H., Ikeda, Y., Matsumoto, K., ... Takaki, A. (2000). Fatal severe vasospasm due to rewarming following hypothermia. Neurologia medico-chirurgica, 40(9), 463-466. https://doi.org/10.2176/nmc.40.463

Fatal severe vasospasm due to rewarming following hypothermia. / Jimbo, Hiroyuki; Dohi, Kenji; Nakamura, Yoshinori; Izumiyama, Hitoshi; Ikeda, Yukio; Matsumoto, Kiyoshi; Kushima, Miki; Takaki, Atsushi.

In: Neurologia medico-chirurgica, Vol. 40, No. 9, 01.01.2000, p. 463-466.

Research output: Contribution to journalArticle

Jimbo, H, Dohi, K, Nakamura, Y, Izumiyama, H, Ikeda, Y, Matsumoto, K, Kushima, M & Takaki, A 2000, 'Fatal severe vasospasm due to rewarming following hypothermia', Neurologia medico-chirurgica, vol. 40, no. 9, pp. 463-466. https://doi.org/10.2176/nmc.40.463
Jimbo H, Dohi K, Nakamura Y, Izumiyama H, Ikeda Y, Matsumoto K et al. Fatal severe vasospasm due to rewarming following hypothermia. Neurologia medico-chirurgica. 2000 Jan 1;40(9):463-466. https://doi.org/10.2176/nmc.40.463
Jimbo, Hiroyuki ; Dohi, Kenji ; Nakamura, Yoshinori ; Izumiyama, Hitoshi ; Ikeda, Yukio ; Matsumoto, Kiyoshi ; Kushima, Miki ; Takaki, Atsushi. / Fatal severe vasospasm due to rewarming following hypothermia. In: Neurologia medico-chirurgica. 2000 ; Vol. 40, No. 9. pp. 463-466.
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