Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia

Akinobu Matsuzaki; Aiko Suminoe; Yuhki Koga; Koichi Kusuhara; Takuya Hara; Reina Ogata; Tetsutaro Sata; Toshiro Hara

doi:10.1080/08880010801938215

Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia

Akinobu Matsuzaki, Aiko Suminoe, Yuhki Koga, Koichi Kusuhara, Takuya Hara, Reina Ogata, Tetsutaro Sata, Toshiro Hara

Pediatrics

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.

Original language	English
Pages (from-to)	237-242
Number of pages	6
Journal	Pediatric Hematology and Oncology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1080/08880010801938215
Publication status	Published - Apr 2008

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/08880010801938215

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abstract = "A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.",

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T1 - Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia

AU - Matsuzaki, Akinobu

AU - Suminoe, Aiko

AU - Koga, Yuhki

AU - Kusuhara, Koichi

AU - Hara, Takuya

AU - Ogata, Reina

AU - Sata, Tetsutaro

AU - Hara, Toshiro

PY - 2008/4

Y1 - 2008/4

N2 - A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.

AB - A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.

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Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia

Abstract

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