Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia

Akinobu Matsuzaki, Aiko Suminoe, Yuhki Koga, Koichi Kusuhara, Takuya Hara, Reina Ogata, Tetsutaro Sata, Toshiro Hara

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalPediatric Hematology and Oncology
Volume25
Issue number3
DOIs
Publication statusPublished - Apr 2008

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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