Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia

Akinobu Matsuzaki, Aiko Suminoe, Yuhki Koga, Koichi Kusuhara, Takuya Hara, Reina Ogata, Tetsutaro Sata, Toshiro Hara

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalPediatric Hematology and Oncology
Volume25
Issue number3
DOIs
Publication statusPublished - Apr 1 2008

Fingerprint

Human Herpesvirus 3
Virus Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Skin
Disseminated Intravascular Coagulation
Immunosuppressive Agents
Dexamethasone
Hepatitis
Oral Administration
Liver Diseases
Antigens
Liver
DNA

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia. / Matsuzaki, Akinobu; Suminoe, Aiko; Koga, Yuhki; Kusuhara, Koichi; Hara, Takuya; Ogata, Reina; Sata, Tetsutaro; Hara, Toshiro.

In: Pediatric Hematology and Oncology, Vol. 25, No. 3, 01.04.2008, p. 237-242.

Research output: Contribution to journalArticle

Matsuzaki, Akinobu ; Suminoe, Aiko ; Koga, Yuhki ; Kusuhara, Koichi ; Hara, Takuya ; Ogata, Reina ; Sata, Tetsutaro ; Hara, Toshiro. / Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia. In: Pediatric Hematology and Oncology. 2008 ; Vol. 25, No. 3. pp. 237-242.
@article{cc1656651886447981ee30b728588577,
title = "Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia",
abstract = "A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.",
author = "Akinobu Matsuzaki and Aiko Suminoe and Yuhki Koga and Koichi Kusuhara and Takuya Hara and Reina Ogata and Tetsutaro Sata and Toshiro Hara",
year = "2008",
month = "4",
day = "1",
doi = "10.1080/08880010801938215",
language = "English",
volume = "25",
pages = "237--242",
journal = "Pediatric Hematology and Oncology",
issn = "0888-0018",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia

AU - Matsuzaki, Akinobu

AU - Suminoe, Aiko

AU - Koga, Yuhki

AU - Kusuhara, Koichi

AU - Hara, Takuya

AU - Ogata, Reina

AU - Sata, Tetsutaro

AU - Hara, Toshiro

PY - 2008/4/1

Y1 - 2008/4/1

N2 - A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.

AB - A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.

UR - http://www.scopus.com/inward/record.url?scp=42449155100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42449155100&partnerID=8YFLogxK

U2 - 10.1080/08880010801938215

DO - 10.1080/08880010801938215

M3 - Article

C2 - 18432508

AN - SCOPUS:42449155100

VL - 25

SP - 237

EP - 242

JO - Pediatric Hematology and Oncology

JF - Pediatric Hematology and Oncology

SN - 0888-0018

IS - 3

ER -