Abstract
A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.
| Original language | English |
|---|---|
| Pages (from-to) | 237-242 |
| Number of pages | 6 |
| Journal | Pediatric Hematology and Oncology |
| Volume | 25 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Apr 1 2008 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology
Cite this
Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia. / Matsuzaki, Akinobu; Suminoe, Aiko; Koga, Yuhki; Kusuhara, Koichi; Hara, Takuya; Ogata, Reina; Sata, Tetsutaro; Hara, Toshiro.
In: Pediatric Hematology and Oncology, Vol. 25, No. 3, 01.04.2008, p. 237-242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fatal visceral varicella-zoster virus infection without skin involvement in a child with acute lymphoblastic leukemia
AU - Matsuzaki, Akinobu
AU - Suminoe, Aiko
AU - Koga, Yuhki
AU - Kusuhara, Koichi
AU - Hara, Takuya
AU - Ogata, Reina
AU - Sata, Tetsutaro
AU - Hara, Toshiro
PY - 2008/4/1
Y1 - 2008/4/1
N2 - A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.
AB - A 5-year-old girl with acute lymphoblastic leukemia in remission suffered from fatal visceral varicella-zoster virus (VZV) infection after the oral administration of a high-dose dexamethasone. She abruptly developed fulminant hepatitis and disseminated intravascular coagulation, and died 3 days later. VZV DNA and antigens were detected in the peripheral blood (6 × 108 copies/mL) and a postmortem liver specimen, respectively. The exposure to VZV was not confirmed and no skin lesions were observed. VZV infection should be considered in patients with unexplained liver dysfunction under severe immunosuppressive condition, even in the absence of viral exposure and skin involvement.
UR - http://www.scopus.com/inward/record.url?scp=42449155100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42449155100&partnerID=8YFLogxK
U2 - 10.1080/08880010801938215
DO - 10.1080/08880010801938215
M3 - Article
C2 - 18432508
AN - SCOPUS:42449155100
VL - 25
SP - 237
EP - 242
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
SN - 0888-0018
IS - 3
ER -