Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins

Makoto Yanagisawa, Takumi Takizawa, Wataru Ochiai, Atsumi Uemura, Kinichi Nakashima, Tetsuya Taga

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Bone morphogenetic proteins (BMPs), a class of cytokines belonging to the transforming growth factor-β superfamily, have been shown to play a wide variety of roles during development including those in the central nervous system. We here report that BMP2, BMP4 and BMP7 have an equivalent potential to inhibit neurogenesis and concomitantly induce astrocytogenesis of mouse fetal neuroepithelial cells. We further show that these BMPs activate a promoter of the gene for negative helix-loop-helix (HLH) factor, Id1, which is known to inhibit the function of such neurogenic transcription factors as Mashl and neurogenin. These results suggest that BMP2, BMP4 and BMP7 alternate the fate of neuroepithelial cells from neuronal type to astrocytic one via a common mechanism involving negative HLH factor.

Original languageEnglish
Pages (from-to)391-396
Number of pages6
JournalNeuroscience Research
Volume41
Issue number4
DOIs
Publication statusPublished - Jan 1 2001
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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