TY - JOUR
T1 - Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins
AU - Yanagisawa, Makoto
AU - Takizawa, Takumi
AU - Ochiai, Wataru
AU - Uemura, Atsumi
AU - Nakashima, Kinichi
AU - Taga, Tetsuya
N1 - Funding Information:
We thank Yamanouchi Pharmaceutical for BMP2, Genetics Institute for BMP4, and Dr T. Kuber Sampath (Creative BioMolecules) for BMP7. We are very much grateful to Yuki Noguchi for her excellent secretarial assistance. We also thank Kaori Kaneko for technical help. This work was supported by Grant-in-Aid from Ministry of Education, Culture, Sports, Science and Technology, Human Frontier Science Program, Ichiro Kanehara Foundation, Inamori Foundation, Kato Memorial Bioscience Foundation, Takeda Science Foundation and Naito Foundation. Makoto Yanagisawa is supported by the Research Fellowships of the Japan Society for Promotion of Science for Young Scientists.
PY - 2001
Y1 - 2001
N2 - Bone morphogenetic proteins (BMPs), a class of cytokines belonging to the transforming growth factor-β superfamily, have been shown to play a wide variety of roles during development including those in the central nervous system. We here report that BMP2, BMP4 and BMP7 have an equivalent potential to inhibit neurogenesis and concomitantly induce astrocytogenesis of mouse fetal neuroepithelial cells. We further show that these BMPs activate a promoter of the gene for negative helix-loop-helix (HLH) factor, Id1, which is known to inhibit the function of such neurogenic transcription factors as Mashl and neurogenin. These results suggest that BMP2, BMP4 and BMP7 alternate the fate of neuroepithelial cells from neuronal type to astrocytic one via a common mechanism involving negative HLH factor.
AB - Bone morphogenetic proteins (BMPs), a class of cytokines belonging to the transforming growth factor-β superfamily, have been shown to play a wide variety of roles during development including those in the central nervous system. We here report that BMP2, BMP4 and BMP7 have an equivalent potential to inhibit neurogenesis and concomitantly induce astrocytogenesis of mouse fetal neuroepithelial cells. We further show that these BMPs activate a promoter of the gene for negative helix-loop-helix (HLH) factor, Id1, which is known to inhibit the function of such neurogenic transcription factors as Mashl and neurogenin. These results suggest that BMP2, BMP4 and BMP7 alternate the fate of neuroepithelial cells from neuronal type to astrocytic one via a common mechanism involving negative HLH factor.
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U2 - 10.1016/S0168-0102(01)00297-8
DO - 10.1016/S0168-0102(01)00297-8
M3 - Article
C2 - 11755226
AN - SCOPUS:0035651187
SN - 0168-0102
VL - 41
SP - 391
EP - 396
JO - Neuroscience Research
JF - Neuroscience Research
IS - 4
ER -