Favorable response obtained by low dose chemotherapy in an elderly patient with extensive small cell lung cancer and renal dysfunction

Katsunada Fujimoto, Taishi Harada, Kentaro Watanabe

Research output: Contribution to journalArticle

Abstract

An 82-year-old man with extensive small cell lung cancer was treated with 2 courses of low dose CPT-11 (40mg/body, day 1, 8 and 15) and carboplatin (100mg/body, day 1). The reduction in tumor sizes evaluated by two-direction measurement was 88%. His creatinin clearance rates before and after chemotherapy were 20 and 28ml/min, respectively. Temporary leukopenia (900/μl) during the second course of chemotherapy was quickly reversed by the administration of G-CSF, without any episode of infection. Low dose CPT-11 and carboplatin seems to be a promising regimen for elderly patients with small cell lung cancer and renal dysfunction. Cancer tends to increase in old age groups. We consider that it is necessary to examine ideal low dose chemotherapies that can be effective yet preserve quality of life.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalJapanese Journal of Geriatrics
Volume42
Issue number4
DOIs
Publication statusPublished - Jan 1 2005

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irinotecan
Small Cell Lung Carcinoma
Carboplatin
Kidney
Drug Therapy
Leukopenia
Granulocyte Colony-Stimulating Factor
Neoplasms
Age Groups
Quality of Life
Infection

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Favorable response obtained by low dose chemotherapy in an elderly patient with extensive small cell lung cancer and renal dysfunction. / Fujimoto, Katsunada; Harada, Taishi; Watanabe, Kentaro.

In: Japanese Journal of Geriatrics, Vol. 42, No. 4, 01.01.2005, p. 453-456.

Research output: Contribution to journalArticle

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