Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Kanae Yumimoto; Keiichi I. Nakayama

doi:10.1080/2162402X.2015.1022308

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Kanae Yumimoto, Keiichi I. Nakayama

Department of Molecular and Cellular Biology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.

Original language	English
Journal	OncoImmunology
Volume	4
Issue number	8
DOIs	https://doi.org/10.1080/2162402X.2015.1022308
Publication status	Published - Aug 3 2015

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Oncology

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title = "Fbxw7 suppresses cancer metastasis by inhibiting niche formation",

abstract = "Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.",

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AB - Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.

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Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Abstract

All Science Journal Classification (ASJC) codes

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