Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Kanae Yumimoto, Keiichi I. Nakayama

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.

Original languageEnglish
JournalOncoImmunology
Volume4
Issue number8
DOIs
Publication statusPublished - Aug 3 2015

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Neoplasm Metastasis
Chemokine CCL2
Mesenchymal Stromal Cells
Neoplasms
Macrophages
Proteins
Myeloid-Derived Suppressor Cells

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology

Cite this

Fbxw7 suppresses cancer metastasis by inhibiting niche formation. / Yumimoto, Kanae; Nakayama, Keiichi I.

In: OncoImmunology, Vol. 4, No. 8, 03.08.2015.

Research output: Contribution to journal › Article

Yumimoto, K & Nakayama, KI 2015, 'Fbxw7 suppresses cancer metastasis by inhibiting niche formation', OncoImmunology, vol. 4, no. 8. https://doi.org/10.1080/2162402X.2015.1022308
Yumimoto K, Nakayama KI. Fbxw7 suppresses cancer metastasis by inhibiting niche formation. OncoImmunology. 2015 Aug 3;4(8). https://doi.org/10.1080/2162402X.2015.1022308
Yumimoto, Kanae ; Nakayama, Keiichi I. / Fbxw7 suppresses cancer metastasis by inhibiting niche formation. In: OncoImmunology. 2015 ; Vol. 4, No. 8.
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