Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Kanae Yumimoto, Keiichi I. Nakayama

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.

Original languageEnglish
Issue number8
Publication statusPublished - Aug 3 2015

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology


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