Abstract
Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.
Original language | English |
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Journal | OncoImmunology |
Volume | 4 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 3 2015 |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Oncology