Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Kanae Yumimoto, Keiichi I. Nakayama

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.

Original languageEnglish
JournalOncoImmunology
Volume4
Issue number8
DOIs
Publication statusPublished - Aug 3 2015

Fingerprint

Neoplasm Metastasis
Chemokine CCL2
Mesenchymal Stromal Cells
Neoplasms
Macrophages
Proteins
Myeloid-Derived Suppressor Cells

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology

Cite this

Fbxw7 suppresses cancer metastasis by inhibiting niche formation. / Yumimoto, Kanae; Nakayama, Keiichi I.

In: OncoImmunology, Vol. 4, No. 8, 03.08.2015.

Research output: Contribution to journalArticle

@article{3a105029b5884f66a4a00d0862a797a8,
title = "Fbxw7 suppresses cancer metastasis by inhibiting niche formation",
abstract = "Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.",
author = "Kanae Yumimoto and Nakayama, {Keiichi I.}",
year = "2015",
month = "8",
day = "3",
doi = "10.1080/2162402X.2015.1022308",
language = "English",
volume = "4",
journal = "OncoImmunology",
issn = "2162-4011",
publisher = "Landes Bioscience",
number = "8",

}

TY - JOUR

T1 - Fbxw7 suppresses cancer metastasis by inhibiting niche formation

AU - Yumimoto, Kanae

AU - Nakayama, Keiichi I.

PY - 2015/8/3

Y1 - 2015/8/3

N2 - Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.

AB - Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.

UR - http://www.scopus.com/inward/record.url?scp=84940489472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940489472&partnerID=8YFLogxK

U2 - 10.1080/2162402X.2015.1022308

DO - 10.1080/2162402X.2015.1022308

M3 - Article

AN - SCOPUS:84940489472

VL - 4

JO - OncoImmunology

JF - OncoImmunology

SN - 2162-4011

IS - 8

ER -