FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation

Keiji Masuda, Randall S. Davis, Takako Maruyama, Jennifer Zhang, Ti He, Max D. Cooper, Jiyang O-Wang, Peter D. Burrows

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A bioinformatics approach has lead to the identification of FcRY, a new Fc receptor related gene. FcRY is predicted to encode a protein with three immunoglobulin (Ig) domains followed by a mucin-like domain containing a proline-rich stalk and a C-terminal leucine rich region. The predicted protein lacks a hydrophobic domain for insertion into the plasma membrane, suggesting that FcRY is an intracellular or secreted protein. This feature is shared with the product of the FcRX/FCRL/FREB gene that is closely linked to FcRY in both human and mouse genomes. Fcry transcripts are first detectable among mouse B lineage cells at the pre-B cell stage. Splenic B cells of the newly formed, follicular, and marginal zone subsets express Fcry, as do germinal center B cells to a lesser extent. FcRY is also expressed in subpopulations of human B cells. A consistent characteristic of FcRY in both species is low level gene expression, which can be further downregulated in normal mouse B cells by signaling through the B cell receptor (BCR) or CD40, thereby suggesting a correlation between cell cycle entrance and diminished FcRY expression. Fcry is upregulated by short-term treatment with BAFF/BLyS, which promotes B cell survival rather than proliferation. LPS induces very rapid but transient enhancement. We observed a pronounced upregulation of Fcry expression in WEHI 231 cells induced by BCR crosslinking to undergo cell cycle arrest prior to apoptosis, consistent with the possible regulation of Fcry expression by cell cycle status.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalGene
Volume363
Issue number1-2
DOIs
Publication statusPublished - Dec 19 2005

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Fc Receptors
Lymphocyte Activation
B-Lymphocytes
Genes
Cell Cycle
Proteins
B-Lymphoid Precursor Cells
Germinal Center
Mucins
Human Genome
Cell Cycle Checkpoints
Computational Biology
Proline
Leucine
Cell Survival
Up-Regulation
Down-Regulation
Cell Membrane
Apoptosis
Gene Expression

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Masuda, K., Davis, R. S., Maruyama, T., Zhang, J., He, T., Cooper, M. D., ... Burrows, P. D. (2005). FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. Gene, 363(1-2), 32-40. https://doi.org/10.1016/j.gene.2005.08.016

FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. / Masuda, Keiji; Davis, Randall S.; Maruyama, Takako; Zhang, Jennifer; He, Ti; Cooper, Max D.; O-Wang, Jiyang; Burrows, Peter D.

In: Gene, Vol. 363, No. 1-2, 19.12.2005, p. 32-40.

Research output: Contribution to journalArticle

Masuda, K, Davis, RS, Maruyama, T, Zhang, J, He, T, Cooper, MD, O-Wang, J & Burrows, PD 2005, 'FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation', Gene, vol. 363, no. 1-2, pp. 32-40. https://doi.org/10.1016/j.gene.2005.08.016
Masuda, Keiji ; Davis, Randall S. ; Maruyama, Takako ; Zhang, Jennifer ; He, Ti ; Cooper, Max D. ; O-Wang, Jiyang ; Burrows, Peter D. / FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. In: Gene. 2005 ; Vol. 363, No. 1-2. pp. 32-40.
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