Fear conditioning induces guinea pig auditory cortex activation by foot shock alone

Yoshinori Ide, Muneyoshi Takahashi, Johan Lauwereyns, Guy Sandner, Minoru Tsukada, Takeshi Aihara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The present study used an optical imaging paradigm to investigate plastic changes in the auditory cortex induced by fear conditioning, in which a sound (conditioned stimulus, CS) was paired with an electric foot-shock (unconditioned stimulus, US). We report that, after conditioning, auditory information could be retrieved on the basis of an electric foot-shock alone. Before conditioning, the auditory cortex showed no response to a foot-shock presented in the absence of sound. In contrast, after conditioning, the mere presentation of a foot-shock without any sound succeeded in eliciting activity in the auditory cortex. Additionally, the magnitude of the optical response in the auditory cortex correlated with variation in the electrocardiogram (correlation coefficient: -0.68). The area activated in the auditory cortex, in response to the electric foot-shock, statistically significantly had a larger cross-correlation value for tone response to the CS sound (12 kHz) compared to the non-CS sounds in normal conditioning group. These results suggest that integration of different sensory modalities in the auditory cortex was established by fear conditioning.

Original languageEnglish
Pages (from-to)67-77
Number of pages11
JournalCognitive Neurodynamics
Volume7
Issue number1
DOIs
Publication statusPublished - Feb 1 2013

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Auditory Cortex
Fear
Foot
Shock
Guinea Pigs
Optical Imaging
Conditioning (Psychology)
Electrocardiography

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience

Cite this

Fear conditioning induces guinea pig auditory cortex activation by foot shock alone. / Ide, Yoshinori; Takahashi, Muneyoshi; Lauwereyns, Johan; Sandner, Guy; Tsukada, Minoru; Aihara, Takeshi.

In: Cognitive Neurodynamics, Vol. 7, No. 1, 01.02.2013, p. 67-77.

Research output: Contribution to journalArticle

Ide, Yoshinori ; Takahashi, Muneyoshi ; Lauwereyns, Johan ; Sandner, Guy ; Tsukada, Minoru ; Aihara, Takeshi. / Fear conditioning induces guinea pig auditory cortex activation by foot shock alone. In: Cognitive Neurodynamics. 2013 ; Vol. 7, No. 1. pp. 67-77.
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