Feasibility and limitations of magnetoencephalographic detection of epileptic discharges: Simultaneous recording of magnetic fields and electrocorticography

H. Shigeto, T. Morioka, K. Hisada, S. Nishio, H. Ishibashi, D. I. Kira, S. Tobimatsu, M. Kato

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)

Abstract

Magnetoencephalography (MEG) is considered clinically useful in localizing the epileptogenic focus in partial epilepsy. However, the relationship between the extent of the brain involved in paroxysmal activities and the magnetic field changes at the scalp has not been fully clarified. Furthermore, whether paroxysmal activities generated in deep brain structures such as the hippocampus can be detected magnetically is uncertain. Eight patients with temporal lobe epilepsy and two with extratemporal lobe epilepsy underwent chronic recording from subdural electrodes. Magnetic and electrocorticographic discharges representing epileptic activity were recorded simultaneously. MEG recorded magnetic field changes originating from paroxysmal activity in the superiolateral cerebral cortex when the amplitudes of the electrical paroxysmal activities exceeded 100 μV and extended over more than 3 cm2 of cortical surface. MEG failed to record paroxysmal activity localized to the medial temporal lobe. MEG is often useful in identifying a spike focus in the superiolateral aspects of the cerebral hemisphere, but not discharges arising from the medial temporal lobe. Rapid decay of the magnetic field is likely to be the reason for this limited sensitivity to medial discharges.

Original languageEnglish
Pages (from-to)531-536
Number of pages6
JournalNeurological Research
Volume24
Issue number6
DOIs
Publication statusPublished - Sep 2002

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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