Background and study aims: Lesions may be missed during colonoscopy because of anatomical features such as mucosal folds. This feasibility study assessed the safety and efficacy of a novel colonoscope with extra-wide angle of view, which provides a simultaneous lateral-backward view to complement the forward view. Patients and methods: Consecutive patients undergoing colonoscopy using the prototype colonoscope were enrolled in this multicenter, single-arm study. The number of adverse events, and the first detection of adenomas during withdrawal by the lateral-backward view and the forward view were evaluated. Results: A total of 47 patients underwent colonoscopy examination to the cecum. The mean insertion and withdrawal times were 6.4±4.9 minutes and 8.6±4.2 minutes, respectively. Of 47 detected polyps, 28 adenomatous polyps were found (mean size 3.3±3.1mm). A total of 29 polyps (61.7%) and 16 adenomatous polyps (57.1%) were first detected with the lateral-backward view. The lateral-backward view first detected 5/6 adenomatous polyps (83.3%) in the ascending colon and all (2/2) adenomatous polyps in the sigmoid colon. No adverse events occurred during the study. Conclusions: This exploratory study suggested that a novel colonoscope with extra-wide angle of view is safe and feasible, and has the potential to improve colorectal adenoma detection. Trial register: UMIN000016450.
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