TY - JOUR
T1 - Feasibility of magnetic resonance redox imaging at low magnetic field
T2 - Comparison at 1 T and 7 T
AU - Nakamura, Mizuki
AU - Shibata, Sayaka
AU - Yamasaki, Toshihide
AU - Ueno, Megumi
AU - Nakanishi, Ikuo
AU - Matsumoto, Ken Ichiro
AU - Kamada, Tadashi
AU - Yamada, Ken Ichi
AU - Aoki, Ichio
N1 - Funding Information:
The authors are grateful to Yoshikazu Ozawa and Nobuhiro Nitta for their help with the MRI operation. This work was partly supported by JSPS KAKENHI Grant Numbers 24390011 and 26461901 (K. M.). This work was partially supported by JSPS KAKENHI Grant Number 16H01363 (K. Y.), by PRESTO from Japan Science and Technology Agency (K. Y.), and by the Platform Project for Supporting in Drug Discovery and Life Science Research from AMED, Japan, (K. Y.).
Publisher Copyright:
© 2017, E-Century Publishing Corporation. All rights reserved.
PY - 2017
Y1 - 2017
N2 - The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tet-ramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T1-weighted images and susceptibility of T1-weighted signals were compared. The nitroxyl radical-based T1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.
AB - The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tet-ramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T1-weighted images and susceptibility of T1-weighted signals were compared. The nitroxyl radical-based T1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.
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M3 - Article
AN - SCOPUS:85032686624
VL - 9
SP - 4481
EP - 4491
JO - American Journal of Translational Research
JF - American Journal of Translational Research
SN - 1943-8141
IS - 10
M1 - AJTR0054131
ER -
