Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T

Mizuki Nakamura, Sayaka Shibata, Toshihide Yamasaki, Megumi Ueno, Ikuo Nakanishi, Ken Ichiro Matsumoto, Tadashi Kamada, Ken Ichi Yamada, Ichio Aoki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tet-ramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T1-weighted images and susceptibility of T1-weighted signals were compared. The nitroxyl radical-based T1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.

Original languageEnglish
Article numberAJTR0054131
Pages (from-to)4481-4491
Number of pages11
JournalAmerican Journal of Translational Research
Volume9
Issue number10
Publication statusPublished - Jan 1 2017

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Magnetic resonance
Magnetic Fields
Oxidation-Reduction
Magnetic Resonance Imaging
Magnetic fields
Imaging techniques
Experiments
Signal detection
Magnetic resonance imaging
Contrast Media
Noise
Brain
Animals
nitroxyl
Fluxes
Scanning

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

Cite this

Nakamura, M., Shibata, S., Yamasaki, T., Ueno, M., Nakanishi, I., Matsumoto, K. I., ... Aoki, I. (2017). Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T. American Journal of Translational Research, 9(10), 4481-4491. [AJTR0054131].

Feasibility of magnetic resonance redox imaging at low magnetic field : Comparison at 1 T and 7 T. / Nakamura, Mizuki; Shibata, Sayaka; Yamasaki, Toshihide; Ueno, Megumi; Nakanishi, Ikuo; Matsumoto, Ken Ichiro; Kamada, Tadashi; Yamada, Ken Ichi; Aoki, Ichio.

In: American Journal of Translational Research, Vol. 9, No. 10, AJTR0054131, 01.01.2017, p. 4481-4491.

Research output: Contribution to journalArticle

Nakamura, M, Shibata, S, Yamasaki, T, Ueno, M, Nakanishi, I, Matsumoto, KI, Kamada, T, Yamada, KI & Aoki, I 2017, 'Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T', American Journal of Translational Research, vol. 9, no. 10, AJTR0054131, pp. 4481-4491.
Nakamura M, Shibata S, Yamasaki T, Ueno M, Nakanishi I, Matsumoto KI et al. Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T. American Journal of Translational Research. 2017 Jan 1;9(10):4481-4491. AJTR0054131.
Nakamura, Mizuki ; Shibata, Sayaka ; Yamasaki, Toshihide ; Ueno, Megumi ; Nakanishi, Ikuo ; Matsumoto, Ken Ichiro ; Kamada, Tadashi ; Yamada, Ken Ichi ; Aoki, Ichio. / Feasibility of magnetic resonance redox imaging at low magnetic field : Comparison at 1 T and 7 T. In: American Journal of Translational Research. 2017 ; Vol. 9, No. 10. pp. 4481-4491.
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