Abstract
The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tet-ramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T1-weighted images and susceptibility of T1-weighted signals were compared. The nitroxyl radical-based T1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.
| Original language | English |
|---|---|
| Article number | AJTR0054131 |
| Pages (from-to) | 4481-4491 |
| Number of pages | 11 |
| Journal | American Journal of Translational Research |
| Volume | 9 |
| Issue number | 10 |
| Publication status | Published - Jan 1 2017 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Clinical Biochemistry
- Cancer Research
Cite this
Feasibility of magnetic resonance redox imaging at low magnetic field : Comparison at 1 T and 7 T. / Nakamura, Mizuki; Shibata, Sayaka; Yamasaki, Toshihide; Ueno, Megumi; Nakanishi, Ikuo; Matsumoto, Ken Ichiro; Kamada, Tadashi; Yamada, Ken Ichi; Aoki, Ichio.
In: American Journal of Translational Research, Vol. 9, No. 10, AJTR0054131, 01.01.2017, p. 4481-4491.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Feasibility of magnetic resonance redox imaging at low magnetic field
T2 - Comparison at 1 T and 7 T
AU - Nakamura, Mizuki
AU - Shibata, Sayaka
AU - Yamasaki, Toshihide
AU - Ueno, Megumi
AU - Nakanishi, Ikuo
AU - Matsumoto, Ken Ichiro
AU - Kamada, Tadashi
AU - Yamada, Ken Ichi
AU - Aoki, Ichio
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tet-ramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T1-weighted images and susceptibility of T1-weighted signals were compared. The nitroxyl radical-based T1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.
AB - The effect of different static magnetic field strengths, 1 T or 7 T, on the quality of nitroxyl radical-based magnetic resonance redox imaging (MRRI) was examined. A stable nitroxyl radical, 3-methoxycarbonyl-2,2,5,5-tet-ramethylpyrrolidine-N-oxyl (MC-PROXYL), was used as a T1 contrast agent. Phantoms and animals were scanned at 1 T and 7 T using a similar gradient echo sequence. The quality of T1-weighted images and susceptibility of T1-weighted signals were compared. The nitroxyl radical-based T1-weighted signal enhancement ratio was higher at 1 T compared with at 7 T when the identical phantom was scanned using a similar gradient echo sequence. The gradient echo scanning at 7 T was sensitive to movement and/or flux of the sample solution, which could result in the distortion of baseline T1-weighted signals. No such wobbling of the signal was observed when the experiment was done at 1 T. The detection at the lower field is less affected by voltex flow in the sample, much stable T1-weighted signal detection is available at the lower field. The visual characteristics of in vivo nitroxyl decay profiles were similar between the 1 T and 7 T experiments, except noises were large at 1 T. The correlation trends of in vivo decay constants among brain regions also similar between 1 T and 7 T experiments. Nitroxyl radical-based MRRI could be an adequate theranostic tool when performed on clinically popular low magnetic field MRI instruments.
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UR - http://www.scopus.com/inward/citedby.url?scp=85032686624&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85032686624
VL - 9
SP - 4481
EP - 4491
JO - American Journal of Translational Research
JF - American Journal of Translational Research
SN - 1943-8141
IS - 10
M1 - AJTR0054131
ER -