Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network

Konosuke Asanou, Naoaki Ono, Chika Iwamoto, Kenoki Ohuchida, Koji Shindo, Shigehiko Kanaya

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In recent years, computer-aided diagnosis based on machine learning, mainly based on Convolutional Neural Network (CNN) has been studied and developed rapidly. Those methods are not only helpful for classification, but also useful for feature extraction from given images, especially encoding image data into discrete representation helps us obtain new knowledge. Previous researches showed that CNN can by trainded for not only dection of cancers but also classification of gene expression subtypes. Although most of these studies are based on supervised learning that needs curated pathological knowledge, it is useful to extract characteristic features in the given images, using unsupervised machine learning in order to obtain new pathological findings. We applied cluster analysis using CNN which is trained based on adversarial training and maximization of mutual information and showed that it can classify those pathological images into discrete categories. Next, we applied our model for comparison of the two staining method in order to evaluate the degree of malignancy according to fibrosis and cell differentiation. The results showed that encoding of the histopathological image into discrete representations helps us to interpret tumor images.

Original languageEnglish
Title of host publicationProceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
EditorsHuiru Zheng, Zoraida Callejas, David Griol, Haiying Wang, Xiaohua Hu, Harald Schmidt, Jan Baumbach, Julie Dickerson, Le Zhang
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2738-2740
Number of pages3
ISBN (Electronic)9781538654880
DOIs
Publication statusPublished - Jan 21 2019
Event2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, Spain
Duration: Dec 3 2018Dec 6 2018

Publication series

NameProceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

Conference

Conference2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
CountrySpain
CityMadrid
Period12/3/1812/6/18

Fingerprint

Cluster analysis
Cluster Analysis
Feature extraction
Neural networks
Learning systems
Computer aided diagnosis
Neoplasms
Supervised learning
Gene expression
Tumors
Cell Differentiation
Fibrosis
Learning
Staining and Labeling
Gene Expression
Research

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics

Cite this

Asanou, K., Ono, N., Iwamoto, C., Ohuchida, K., Shindo, K., & Kanaya, S. (2019). Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. In H. Zheng, Z. Callejas, D. Griol, H. Wang, X. Hu, H. Schmidt, J. Baumbach, J. Dickerson, ... L. Zhang (Eds.), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 (pp. 2738-2740). [8621323] (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2018.8621323

Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. / Asanou, Konosuke; Ono, Naoaki; Iwamoto, Chika; Ohuchida, Kenoki; Shindo, Koji; Kanaya, Shigehiko.

Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. ed. / Huiru Zheng; Zoraida Callejas; David Griol; Haiying Wang; Xiaohua Hu; Harald Schmidt; Jan Baumbach; Julie Dickerson; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. p. 2738-2740 8621323 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Asanou, K, Ono, N, Iwamoto, C, Ohuchida, K, Shindo, K & Kanaya, S 2019, Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. in H Zheng, Z Callejas, D Griol, H Wang, X Hu, H Schmidt, J Baumbach, J Dickerson & L Zhang (eds), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018., 8621323, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Institute of Electrical and Electronics Engineers Inc., pp. 2738-2740, 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Madrid, Spain, 12/3/18. https://doi.org/10.1109/BIBM.2018.8621323
Asanou K, Ono N, Iwamoto C, Ohuchida K, Shindo K, Kanaya S. Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. In Zheng H, Callejas Z, Griol D, Wang H, Hu X, Schmidt H, Baumbach J, Dickerson J, Zhang L, editors, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. Institute of Electrical and Electronics Engineers Inc. 2019. p. 2738-2740. 8621323. (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). https://doi.org/10.1109/BIBM.2018.8621323
Asanou, Konosuke ; Ono, Naoaki ; Iwamoto, Chika ; Ohuchida, Kenoki ; Shindo, Koji ; Kanaya, Shigehiko. / Feature extraction and Cluster analysis of Pancreatic Pathological Image Based on Unsupervised Convolutional Neural Network. Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. editor / Huiru Zheng ; Zoraida Callejas ; David Griol ; Haiying Wang ; Xiaohua Hu ; Harald Schmidt ; Jan Baumbach ; Julie Dickerson ; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 2738-2740 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).
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