Feeding suppression elicited by electrical and chemical stimulations of monkey hypothalamus

Atsushi Takaki, S. Aou, Y. Oomura, E. Okada, T. Hori

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The effects of electrical (ES) and chemical stimulations of the hypothalamus were investigated in monkeys during bar-press feeding. ES elicited both prolonged and nonprolonged types of suppression of bar-press feeding in hungry animals. Prolonged type suppression persisted for >1 min beyond one or more post-ES trials and was found after ES of the dorsomedial hypothalamus (DMH), the ventromedial hypothalamus (VMH), and the ventromedial part of the lateral hypothalamic area (LHA). Non-prolonged type suppression was observed only during ES at some sites of both in hypothalamic and extrahypothalamic areas. A microinjection of glutamate into the VMH and the DMH, but not into the LHA, was able to reproduce the ES-induced prolonged type suppression. In contrast, the ES of the LHA, but not the VMH and DMH, in a satiated state provoked feeding. The results, together with the previous findings, suggest that the neuronal inhibitory mechanism of feeding exists in the VMH and DMH, while both the neuronal facilitatory and axonal inhibitory mechanisms in the LHA are involved in the feeding regulation, and these mechanisms of the LHA are affected by the hunger/satiety state.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume262
Issue number4 31-4
Publication statusPublished - Jan 1 1992

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Chemical Stimulation
Electric Stimulation
Hypothalamus
Haplorhini
Lateral Hypothalamic Area
Hunger
Microinjections
Glutamic Acid

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Feeding suppression elicited by electrical and chemical stimulations of monkey hypothalamus. / Takaki, Atsushi; Aou, S.; Oomura, Y.; Okada, E.; Hori, T.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 262, No. 4 31-4, 01.01.1992.

Research output: Contribution to journalArticle

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AB - The effects of electrical (ES) and chemical stimulations of the hypothalamus were investigated in monkeys during bar-press feeding. ES elicited both prolonged and nonprolonged types of suppression of bar-press feeding in hungry animals. Prolonged type suppression persisted for >1 min beyond one or more post-ES trials and was found after ES of the dorsomedial hypothalamus (DMH), the ventromedial hypothalamus (VMH), and the ventromedial part of the lateral hypothalamic area (LHA). Non-prolonged type suppression was observed only during ES at some sites of both in hypothalamic and extrahypothalamic areas. A microinjection of glutamate into the VMH and the DMH, but not into the LHA, was able to reproduce the ES-induced prolonged type suppression. In contrast, the ES of the LHA, but not the VMH and DMH, in a satiated state provoked feeding. The results, together with the previous findings, suggest that the neuronal inhibitory mechanism of feeding exists in the VMH and DMH, while both the neuronal facilitatory and axonal inhibitory mechanisms in the LHA are involved in the feeding regulation, and these mechanisms of the LHA are affected by the hunger/satiety state.

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