Fetal aortic distension waveforms for evaluating cardiac function and changes in blood pressure: Fetal lamb validation

Yasuyuki Fujita, Shoji Satoh, Yasuo Yumoto, Tsuyoshi Koga, Naoko Kinukawa, Hitoo Nakano

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Abstract

Aim: To investigate which part of the fetal aortic distension waveform is mainly influenced by changes in fetal cardiac contractility and aortic blood pressure. Methods: In acute preparation, aortic distension waveforms were recorded using an echo-tracking system, and aortic and left ventricular pressure waveforms were obtained from six late-gestation catheterized fetal lambs. Dobutamine and angiotensin II were separately infused and the correlations between the maximum value in the first derivative of left ventricle pressure waveforms (Max dP/dt) and fetal blood pressure, and the parameters obtained from aortic distension waveforms were analyzed using linear regression analysis. Results: With a change in cardiac contractility, the maximum value of first derivative of the systolic rising slope in the aortic distension waveform had a positive correlation with Max dP/dt (r = 0.93, P < 0.0001). With changes in fetal blood pressure, both the amplitude and the ratio of increase from the end diastolic diameter obtained from the aortic distension waveform had a significant positive correlation with aortic blood pressure amplitude (r = 0.60, P < 0.01; r = 0.61, P < 0.01, respectively). Conclusion: The maximum first derivative of the systolic rising slope in the aortic distension waveform and the amplitude in the aortic distension waveform enable us to non-invasively substitute for fetal cardiac contractility and aortic blood pressure amplitude, respectively.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalJournal of Obstetrics and Gynaecology Research
Volume32
Issue number2
DOIs
Publication statusPublished - Apr 1 2006

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All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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