FGF8 coordinates tissue elongation and cell epithelialization during early kidney tubulogenesis

Yuji Atsuta, Yoshiko Takahashi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

When a tubular structure forms during early embryogenesis, tubular elongation and lumen formation (epithelialization) proceed simultaneously in a spatiotemporally coordinated manner. We here demonstrate, using theWolffian duct (WD) of early chicken embryos, that this coordination is regulated by the expression of FGF8, which shifts posteriorly during body axis elongation. FGF8 acts as a chemoattractant on the leader cells of the elongating WD and prevents them from epithelialization, whereas static (‘rear’) cells that receive progressively less FGF8 undergo epithelialization to form a lumen. Thus, FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation. The posteriorly shifting FGF8 is also known to regulate somite segmentation, suggesting that multiple types of tissue morphogenesis are coordinately regulated by macroscopic changes in body growth.

Original languageEnglish
Pages (from-to)2329-2337
Number of pages9
JournalDevelopment (Cambridge)
Volume142
Issue number13
DOIs
Publication statusPublished - Jul 1 2015

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology

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