Fibrosis in nonalcoholic fatty liver disease

Noninvasive assessment using computed tomography volumetry

Nobuhiro Fujita, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, yasuhiro ushijima, Yukihisa Takayama, Daisuke Okamoto, Ken Shirabe, Tomoharu Yoshizumi, Kazuhiro Kotoh, Norihiro Furusyo, Tomoyuki Hida, Yoshinao Oda, Taisuke Fujioka, Hiroshi Honda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

AIM To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment (LLS), left medial segment, caudate lobe, and right lobe (RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman's rank correlation coefficient. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis stage. RESULTS The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage (r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage (r = -0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis (F3-F4) was 4.789%, 85.7% sensitivity and 94.1% specificity. CONCLUSION The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients.

Original languageEnglish
Pages (from-to)8949-8955
Number of pages7
JournalWorld Journal of Gastroenterology
Volume22
Issue number40
DOIs
Publication statusPublished - Oct 28 2016

Fingerprint

Fibrosis
Tomography
ROC Curve
Non-alcoholic Fatty Liver Disease
Cone-Beam Computed Tomography
Liver
Nonparametric Statistics
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Fibrosis in nonalcoholic fatty liver disease : Noninvasive assessment using computed tomography volumetry. / Fujita, Nobuhiro; Nishie, Akihiro; Asayama, Yoshiki; Ishigami, Kousei; ushijima, yasuhiro; Takayama, Yukihisa; Okamoto, Daisuke; Shirabe, Ken; Yoshizumi, Tomoharu; Kotoh, Kazuhiro; Furusyo, Norihiro; Hida, Tomoyuki; Oda, Yoshinao; Fujioka, Taisuke; Honda, Hiroshi.

In: World Journal of Gastroenterology, Vol. 22, No. 40, 28.10.2016, p. 8949-8955.

Research output: Contribution to journalArticle

Fujita, Nobuhiro ; Nishie, Akihiro ; Asayama, Yoshiki ; Ishigami, Kousei ; ushijima, yasuhiro ; Takayama, Yukihisa ; Okamoto, Daisuke ; Shirabe, Ken ; Yoshizumi, Tomoharu ; Kotoh, Kazuhiro ; Furusyo, Norihiro ; Hida, Tomoyuki ; Oda, Yoshinao ; Fujioka, Taisuke ; Honda, Hiroshi. / Fibrosis in nonalcoholic fatty liver disease : Noninvasive assessment using computed tomography volumetry. In: World Journal of Gastroenterology. 2016 ; Vol. 22, No. 40. pp. 8949-8955.
@article{d2c1b26e9dc34c6a9201da9e203608ee,
title = "Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry",
abstract = "AIM To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment (LLS), left medial segment, caudate lobe, and right lobe (RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman's rank correlation coefficient. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis stage. RESULTS The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage (r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage (r = -0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis (F3-F4) was 4.789{\%}, 85.7{\%} sensitivity and 94.1{\%} specificity. CONCLUSION The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients.",
author = "Nobuhiro Fujita and Akihiro Nishie and Yoshiki Asayama and Kousei Ishigami and yasuhiro ushijima and Yukihisa Takayama and Daisuke Okamoto and Ken Shirabe and Tomoharu Yoshizumi and Kazuhiro Kotoh and Norihiro Furusyo and Tomoyuki Hida and Yoshinao Oda and Taisuke Fujioka and Hiroshi Honda",
year = "2016",
month = "10",
day = "28",
doi = "10.3748/wjg.v22.i40.8949",
language = "English",
volume = "22",
pages = "8949--8955",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "40",

}

TY - JOUR

T1 - Fibrosis in nonalcoholic fatty liver disease

T2 - Noninvasive assessment using computed tomography volumetry

AU - Fujita, Nobuhiro

AU - Nishie, Akihiro

AU - Asayama, Yoshiki

AU - Ishigami, Kousei

AU - ushijima, yasuhiro

AU - Takayama, Yukihisa

AU - Okamoto, Daisuke

AU - Shirabe, Ken

AU - Yoshizumi, Tomoharu

AU - Kotoh, Kazuhiro

AU - Furusyo, Norihiro

AU - Hida, Tomoyuki

AU - Oda, Yoshinao

AU - Fujioka, Taisuke

AU - Honda, Hiroshi

PY - 2016/10/28

Y1 - 2016/10/28

N2 - AIM To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment (LLS), left medial segment, caudate lobe, and right lobe (RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman's rank correlation coefficient. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis stage. RESULTS The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage (r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage (r = -0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis (F3-F4) was 4.789%, 85.7% sensitivity and 94.1% specificity. CONCLUSION The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients.

AB - AIM To evaluate the diagnostic performance of computed tomography (CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD). METHODS A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment (LLS), left medial segment, caudate lobe, and right lobe (RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman's rank correlation coefficient. A receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis stage. RESULTS The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage (r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage (r = -0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis (F3-F4) was 4.789%, 85.7% sensitivity and 94.1% specificity. CONCLUSION The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients.

UR - http://www.scopus.com/inward/record.url?scp=84992697455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992697455&partnerID=8YFLogxK

U2 - 10.3748/wjg.v22.i40.8949

DO - 10.3748/wjg.v22.i40.8949

M3 - Article

VL - 22

SP - 8949

EP - 8955

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 40

ER -