First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution

Akio Ojida, Yasuko Mito-Oka, Masa Aki Inoue, Itaru Hamachi

Research output: Contribution to journalArticle

307 Citations (Scopus)

Abstract

The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (≥ 107 M-1) in aqueous solution.

Original languageEnglish
Pages (from-to)6256-6258
Number of pages3
JournalJournal of the American Chemical Society
Volume124
Issue number22
DOIs
Publication statusPublished - Jun 5 2002

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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