First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution

Akio Ojida; Yasuko Mito-Oka; Masa Aki Inoue; Itaru Hamachi

doi:10.1021/ja025761b

First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution

Akio Ojida, Yasuko Mito-Oka, Masa Aki Inoue, Itaru Hamachi

Molecular Bioinformatics

Research output: Contribution to journal › Article › peer-review

329 Citations (Scopus)

Abstract

The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (≥ 10⁷ M^-1) in aqueous solution.

Original language	English
Pages (from-to)	6256-6258
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	124
Issue number	22
DOIs	https://doi.org/10.1021/ja025761b
Publication status	Published - Jun 5 2002

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja025761b

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title = "First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution",

abstract = "The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (≥ 107 M-1) in aqueous solution.",

author = "Akio Ojida and Yasuko Mito-Oka and Inoue, {Masa Aki} and Itaru Hamachi",

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AU - Mito-Oka, Yasuko

AU - Inoue, Masa Aki

AU - Hamachi, Itaru

PY - 2002/6/5

Y1 - 2002/6/5

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First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution

Abstract

All Science Journal Classification (ASJC) codes

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