First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution

Akio Ojida, Yasuko Mito-Oka, Masa Aki Inoue, Itaru Hamachi

Research output: Contribution to journalArticle

304 Citations (Scopus)

Abstract

The first fluorescent chemosensors toward a native phosphorylated peptide are successfully synthesized. Dinuclear zinc(II)-dipicolylamine-based anthracene (1, 2) can selectively recognize and sense phosphorylated species with an increase in the fluorescence intensity. We also demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity (≥ 107 M-1) in aqueous solution.

Original languageEnglish
Pages (from-to)6256-6258
Number of pages3
JournalJournal of the American Chemical Society
Volume124
Issue number22
DOIs
Publication statusPublished - Jun 5 2002

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Artificial Receptors
Peptides
Anthracene
Zinc
Fluorescence

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution. / Ojida, Akio; Mito-Oka, Yasuko; Inoue, Masa Aki; Hamachi, Itaru.

In: Journal of the American Chemical Society, Vol. 124, No. 22, 05.06.2002, p. 6256-6258.

Research output: Contribution to journalArticle

Ojida, Akio ; Mito-Oka, Yasuko ; Inoue, Masa Aki ; Hamachi, Itaru. / First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution. In: Journal of the American Chemical Society. 2002 ; Vol. 124, No. 22. pp. 6256-6258.
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