First Functionalized MRI Contrast Agent Recognizing Vascular Lesions

Tatsuhiro Yamamoto, Kenjiro Ikuta, Keiji Oi, Kohtaro Abe, Toyokazu Uwatoku, Masaharu Murata, Noboru Shigetani, Kengo Yoshimitsu, Hiroaki Shimokawa, Yoshiki Katayama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MR1. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water's protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.

Original languageEnglish
Pages (from-to)5-7
Number of pages3
Journalanalytical sciences
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2004

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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    Yamamoto, T., Ikuta, K., Oi, K., Abe, K., Uwatoku, T., Murata, M., Shigetani, N., Yoshimitsu, K., Shimokawa, H., & Katayama, Y. (2004). First Functionalized MRI Contrast Agent Recognizing Vascular Lesions. analytical sciences, 20(1), 5-7. https://doi.org/10.2116/analsci.20.5