First total synthesis of dl-duocarmycin A

Yasumichi Fukuda, Kazuhiko Nakatani, Yoshio Ito, Shiro Terashima

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The title synthesis could be achieved by featuring introduction of a methoxycarbonyl group into the C-4 position of a 5-aminoindoline nucleus by way of an isatin derivative and subsequent ring closure to a methyl 2-methylindoxyl-2-carboxylate system by the Dieckmann cyclization.

Original languageEnglish
Pages (from-to)6699-6702
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number46
DOIs
Publication statusPublished - Jan 1 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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