In this study, we achieved the first total synthesis of natural prunustatin A (1), a novel inhibitor of glucose-regulated protein 78 (GRP78) expression. A key feature included a 15-membered ring macrocyclization, which was successfully accomplished by employing Shiina macrolactonization using 2-methyl-6- nitrobenzoic anhydride (MNBA) and 4-dimethylaminopyridine (DMAP).
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry