Abstract
In this study, we achieved the first total synthesis of natural prunustatin A (1), a novel inhibitor of glucose-regulated protein 78 (GRP78) expression. A key feature included a 15-membered ring macrocyclization, which was successfully accomplished by employing Shiina macrolactonization using 2-methyl-6- nitrobenzoic anhydride (MNBA) and 4-dimethylaminopyridine (DMAP).
| Original language | English |
|---|---|
| Pages (from-to) | 1175-1177 |
| Number of pages | 3 |
| Journal | Tetrahedron Letters |
| Volume | 55 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Feb 5 2014 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Yamakoshi, S., & Kawanishi, E. (2014). First total synthesis of prunustatin A. Tetrahedron Letters, 55(6), 1175-1177. https://doi.org/10.1016/j.tetlet.2013.12.106