Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats

Fuminori Kawabata, Takafumi Mizushige, Keisuke Uozumi, Kohsuke Hayamizu, Li Han, Tomoko Tsuji, Taro Kishida

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In our previous study, fish protein was proven to reduce serum lipids and body fat accumulation by skeletal muscle hypertrophy and enhancing basal energy expenditure in rats. In the present study, we examined the precise effects of fish protein intake on different skeletal muscle fiber types and metabolic gene expression of the muscle. Fish protein increased fast-twitch muscle weight, reduced liver triglycerides and serum glucose levels, compared with the casein diet after 6 or 8 weeks of feeding. Furthermore, fish protein upregulated the gene expressions of a fasttwitch muscle-type marker and a glucose transporter in the muscle. These results suggest that fish protein induces fast-muscle hypertrophy, and the enhancement of basal energy expenditure by muscle hypertrophy and the increase in muscle glucose uptake reduced liver lipids and serum glucose levels. The present results also imply that fish protein intake causes a slow-to-fast shift in muscle fiber type.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalBioscience, Biotechnology and Biochemistry
Volume79
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

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Fish Proteins
Liver
Hypertrophy
Muscle
Rats
Lipids
Glucose
Muscles
Serum
Energy Metabolism
Gene expression
Gene Expression
Facilitative Glucose Transport Proteins
Skeletal Muscle Fibers
Caseins
Fibers
Adipose Tissue
Nutrition
Skeletal Muscle
Triglycerides

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats. / Kawabata, Fuminori; Mizushige, Takafumi; Uozumi, Keisuke; Hayamizu, Kohsuke; Han, Li; Tsuji, Tomoko; Kishida, Taro.

In: Bioscience, Biotechnology and Biochemistry, Vol. 79, No. 1, 01.01.2015, p. 109-116.

Research output: Contribution to journalArticle

Kawabata, Fuminori ; Mizushige, Takafumi ; Uozumi, Keisuke ; Hayamizu, Kohsuke ; Han, Li ; Tsuji, Tomoko ; Kishida, Taro. / Fish protein intake induces fast-muscle hypertrophy and reduces liver lipids and serum glucose levels in rats. In: Bioscience, Biotechnology and Biochemistry. 2015 ; Vol. 79, No. 1. pp. 109-116.
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