FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer

Makoto Habara; Yuki Sato; Takahiro Goshima; Masashi Sakurai; Hiroyuki Imai; Hideyuki Shimizu; Yuta Katayama; Shunsuke Hanaki; Takahiro Masaki; Masahiro Morimoto; Sayaka Nishikawa; Tatsuya Toyama; Midori Shimada

doi:10.1073/pnas.2110256119

FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer

Makoto Habara, Yuki Sato, Takahiro Goshima, Masashi Sakurai, Hiroyuki Imai, Hideyuki Shimizu, Yuta Katayama, Shunsuke Hanaki, Takahiro Masaki, Masahiro Morimoto, Sayaka Nishikawa, Tatsuya Toyama, Midori Shimada

Department of Molecular and Cellular Biology

Research output: Contribution to journal › Article › peer-review

Abstract

SignificanceEstrogen receptor α (ERα) is a transcription factor that induces cell proliferation and exhibits increased expression in a large subset of breast cancers. We comprehensively searched for indicators of poor prognosis in ERα-positive breast cancer through the multiple databases, including interactome, transcriptome, and survival analysis, and identified FKBP52. We found that two immunophilins, FKBP52 and FKBP51, have opposing effects on ERα stability and propose that therapeutic targeting of FKBP52 could be useful for the prevention and treatment of ERα-positive breast cancers, including endocrine therapy-resistant breast cancers.

Original language	English
Pages (from-to)	e2110256119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	15
DOIs	https://doi.org/10.1073/pnas.2110256119
Publication status	Published - Apr 12 2022

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Habara, M., Sato, Y., Goshima, T., Sakurai, M., Imai, H., Shimizu, H., Katayama, Y., Hanaki, S., Masaki, T., Morimoto, M., Nishikawa, S., Toyama, T., & Shimada, M. (2022). FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 119(15), e2110256119. https://doi.org/10.1073/pnas.2110256119

Habara, M, Sato, Y, Goshima, T, Sakurai, M, Imai, H, Shimizu, H, Katayama, Y, Hanaki, S, Masaki, T, Morimoto, M, Nishikawa, S, Toyama, T & Shimada, M 2022, 'FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer', Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 15, pp. e2110256119. https://doi.org/10.1073/pnas.2110256119

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abstract = "SignificanceEstrogen receptor α (ERα) is a transcription factor that induces cell proliferation and exhibits increased expression in a large subset of breast cancers. We comprehensively searched for indicators of poor prognosis in ERα-positive breast cancer through the multiple databases, including interactome, transcriptome, and survival analysis, and identified FKBP52. We found that two immunophilins, FKBP52 and FKBP51, have opposing effects on ERα stability and propose that therapeutic targeting of FKBP52 could be useful for the prevention and treatment of ERα-positive breast cancers, including endocrine therapy-resistant breast cancers.",

author = "Makoto Habara and Yuki Sato and Takahiro Goshima and Masashi Sakurai and Hiroyuki Imai and Hideyuki Shimizu and Yuta Katayama and Shunsuke Hanaki and Takahiro Masaki and Masahiro Morimoto and Sayaka Nishikawa and Tatsuya Toyama and Midori Shimada",

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doi = "10.1073/pnas.2110256119",

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T1 - FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer

AU - Habara, Makoto

AU - Sato, Yuki

AU - Goshima, Takahiro

AU - Sakurai, Masashi

AU - Imai, Hiroyuki

AU - Shimizu, Hideyuki

AU - Katayama, Yuta

AU - Hanaki, Shunsuke

AU - Masaki, Takahiro

AU - Morimoto, Masahiro

AU - Nishikawa, Sayaka

AU - Toyama, Tatsuya

AU - Shimada, Midori

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AB - SignificanceEstrogen receptor α (ERα) is a transcription factor that induces cell proliferation and exhibits increased expression in a large subset of breast cancers. We comprehensively searched for indicators of poor prognosis in ERα-positive breast cancer through the multiple databases, including interactome, transcriptome, and survival analysis, and identified FKBP52. We found that two immunophilins, FKBP52 and FKBP51, have opposing effects on ERα stability and propose that therapeutic targeting of FKBP52 could be useful for the prevention and treatment of ERα-positive breast cancers, including endocrine therapy-resistant breast cancers.

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FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer

Abstract

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