Abstract
Aims: CD10+ colorectal carcinomas have a high risk of giving rise to liver metastasis. The aim was to examine phenotypic expression in colorectal neoplasia and to elucidate changes in such expression through the adenoma-carcinoma sequence. Methods and results: We examined the expression of various proteins immunohistochemically in 111 flat [non-polypoid growth (NPG)] colorectal neoplasms, categorized into 28 low-grade (NPG-LGN), 44 high-grades (NPG-HGN) and 39 cases of invasive neoplasia (NPG-IN), as well as in 96 polypoid [polypoid growth (PG)] neoplasms, categorized into 26 PG-LGN, 39 PG-HGN and 31 PG-IN according to the Vienna classification. CD10 was more frequently expressed in NPG than in PG neoplasia. MUC2 and MUC5AC were more frequently expressed in PG than in NPG neoplasias. Nuclear β-catenin was more frequently expressed in NPG-LGN than in PG-LGN. No difference in p53 expression was found between NPG and PG neoplasia. Conclusions: From the viewpoint of the expression of CD10 and β-catenin, it would appear that NPG-LGN differs significantly from PG-LGN, thereby indicating that NPG-LGN is a precursor of CD10+ carcinoma. It is important to ensure that NPG neoplasia is not overlooked if cases of CD10+ carcinoma are to be detected at an early stage.
| Original language | English |
|---|---|
| Pages (from-to) | 569-577 |
| Number of pages | 9 |
| Journal | Histopathology |
| Volume | 52 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Apr 1 2008 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Histology
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Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and β-catenin expression : A different pathway from the polypoid adenoma-carcinoma sequence. / Koga, Yuhki; Yao, T.; Hirahashi, Minako; Kumashiro, Y.; Ohji, Y.; Yamada, T.; Tanaka, M.; Tsuneyoshi, M.
In: Histopathology, Vol. 52, No. 5, 01.04.2008, p. 569-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and β-catenin expression
T2 - A different pathway from the polypoid adenoma-carcinoma sequence
AU - Koga, Yuhki
AU - Yao, T.
AU - Hirahashi, Minako
AU - Kumashiro, Y.
AU - Ohji, Y.
AU - Yamada, T.
AU - Tanaka, M.
AU - Tsuneyoshi, M.
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Aims: CD10+ colorectal carcinomas have a high risk of giving rise to liver metastasis. The aim was to examine phenotypic expression in colorectal neoplasia and to elucidate changes in such expression through the adenoma-carcinoma sequence. Methods and results: We examined the expression of various proteins immunohistochemically in 111 flat [non-polypoid growth (NPG)] colorectal neoplasms, categorized into 28 low-grade (NPG-LGN), 44 high-grades (NPG-HGN) and 39 cases of invasive neoplasia (NPG-IN), as well as in 96 polypoid [polypoid growth (PG)] neoplasms, categorized into 26 PG-LGN, 39 PG-HGN and 31 PG-IN according to the Vienna classification. CD10 was more frequently expressed in NPG than in PG neoplasia. MUC2 and MUC5AC were more frequently expressed in PG than in NPG neoplasias. Nuclear β-catenin was more frequently expressed in NPG-LGN than in PG-LGN. No difference in p53 expression was found between NPG and PG neoplasia. Conclusions: From the viewpoint of the expression of CD10 and β-catenin, it would appear that NPG-LGN differs significantly from PG-LGN, thereby indicating that NPG-LGN is a precursor of CD10+ carcinoma. It is important to ensure that NPG neoplasia is not overlooked if cases of CD10+ carcinoma are to be detected at an early stage.
AB - Aims: CD10+ colorectal carcinomas have a high risk of giving rise to liver metastasis. The aim was to examine phenotypic expression in colorectal neoplasia and to elucidate changes in such expression through the adenoma-carcinoma sequence. Methods and results: We examined the expression of various proteins immunohistochemically in 111 flat [non-polypoid growth (NPG)] colorectal neoplasms, categorized into 28 low-grade (NPG-LGN), 44 high-grades (NPG-HGN) and 39 cases of invasive neoplasia (NPG-IN), as well as in 96 polypoid [polypoid growth (PG)] neoplasms, categorized into 26 PG-LGN, 39 PG-HGN and 31 PG-IN according to the Vienna classification. CD10 was more frequently expressed in NPG than in PG neoplasia. MUC2 and MUC5AC were more frequently expressed in PG than in NPG neoplasias. Nuclear β-catenin was more frequently expressed in NPG-LGN than in PG-LGN. No difference in p53 expression was found between NPG and PG neoplasia. Conclusions: From the viewpoint of the expression of CD10 and β-catenin, it would appear that NPG-LGN differs significantly from PG-LGN, thereby indicating that NPG-LGN is a precursor of CD10+ carcinoma. It is important to ensure that NPG neoplasia is not overlooked if cases of CD10+ carcinoma are to be detected at an early stage.
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UR - http://www.scopus.com/inward/citedby.url?scp=41149103828&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2559.2008.02996.x
DO - 10.1111/j.1365-2559.2008.02996.x
M3 - Article
VL - 52
SP - 569
EP - 577
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 5
ER -