Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and β-catenin expression

A different pathway from the polypoid adenoma-carcinoma sequence

Yuhki Koga, T. Yao, Minako Hirahashi, Y. Kumashiro, Y. Ohji, T. Yamada, M. Tanaka, M. Tsuneyoshi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Aims: CD10+ colorectal carcinomas have a high risk of giving rise to liver metastasis. The aim was to examine phenotypic expression in colorectal neoplasia and to elucidate changes in such expression through the adenoma-carcinoma sequence. Methods and results: We examined the expression of various proteins immunohistochemically in 111 flat [non-polypoid growth (NPG)] colorectal neoplasms, categorized into 28 low-grade (NPG-LGN), 44 high-grades (NPG-HGN) and 39 cases of invasive neoplasia (NPG-IN), as well as in 96 polypoid [polypoid growth (PG)] neoplasms, categorized into 26 PG-LGN, 39 PG-HGN and 31 PG-IN according to the Vienna classification. CD10 was more frequently expressed in NPG than in PG neoplasia. MUC2 and MUC5AC were more frequently expressed in PG than in NPG neoplasias. Nuclear β-catenin was more frequently expressed in NPG-LGN than in PG-LGN. No difference in p53 expression was found between NPG and PG neoplasia. Conclusions: From the viewpoint of the expression of CD10 and β-catenin, it would appear that NPG-LGN differs significantly from PG-LGN, thereby indicating that NPG-LGN is a precursor of CD10+ carcinoma. It is important to ensure that NPG neoplasia is not overlooked if cases of CD10+ carcinoma are to be detected at an early stage.

Original languageEnglish
Pages (from-to)569-577
Number of pages9
JournalHistopathology
Volume52
Issue number5
DOIs
Publication statusPublished - Apr 1 2008

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Catenins
Adenoma
Carcinoma
Growth
Neoplasms
Colorectal Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and β-catenin expression : A different pathway from the polypoid adenoma-carcinoma sequence. / Koga, Yuhki; Yao, T.; Hirahashi, Minako; Kumashiro, Y.; Ohji, Y.; Yamada, T.; Tanaka, M.; Tsuneyoshi, M.

In: Histopathology, Vol. 52, No. 5, 01.04.2008, p. 569-577.

Research output: Contribution to journalArticle

Koga, Yuhki ; Yao, T. ; Hirahashi, Minako ; Kumashiro, Y. ; Ohji, Y. ; Yamada, T. ; Tanaka, M. ; Tsuneyoshi, M. / Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and β-catenin expression : A different pathway from the polypoid adenoma-carcinoma sequence. In: Histopathology. 2008 ; Vol. 52, No. 5. pp. 569-577.
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abstract = "Aims: CD10+ colorectal carcinomas have a high risk of giving rise to liver metastasis. The aim was to examine phenotypic expression in colorectal neoplasia and to elucidate changes in such expression through the adenoma-carcinoma sequence. Methods and results: We examined the expression of various proteins immunohistochemically in 111 flat [non-polypoid growth (NPG)] colorectal neoplasms, categorized into 28 low-grade (NPG-LGN), 44 high-grades (NPG-HGN) and 39 cases of invasive neoplasia (NPG-IN), as well as in 96 polypoid [polypoid growth (PG)] neoplasms, categorized into 26 PG-LGN, 39 PG-HGN and 31 PG-IN according to the Vienna classification. CD10 was more frequently expressed in NPG than in PG neoplasia. MUC2 and MUC5AC were more frequently expressed in PG than in NPG neoplasias. Nuclear β-catenin was more frequently expressed in NPG-LGN than in PG-LGN. No difference in p53 expression was found between NPG and PG neoplasia. Conclusions: From the viewpoint of the expression of CD10 and β-catenin, it would appear that NPG-LGN differs significantly from PG-LGN, thereby indicating that NPG-LGN is a precursor of CD10+ carcinoma. It is important to ensure that NPG neoplasia is not overlooked if cases of CD10+ carcinoma are to be detected at an early stage.",
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AU - Hirahashi, Minako

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AU - Tsuneyoshi, M.

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